TLR2 in Pleural Fluid Is Modulated by Talc Particles during Pleurodesis
Joint Authors
Kondelkova, Katerina
Mandak, Jiri
Habal, Petr
Jankovicova, Karolina
Andrys, Ctirad
Krejsek, Jan
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The aim of this study was to examine the role of TLR2 molecule in pleural space during thoracoscopic talc pleurodesis period in patients with malignant pleural effusion.
We analyzed TLR2 molecule in soluble form as well as on membrane of granulocytes in pleural fluid.
Pleural fluid examination was done at three intervals during pleurodesis procedure: 1st—before the thoracoscopic procedure, 2nd—2 hours after the terminating thoracoscopic procedure with talc insufflation, 3rd—24 hours after the thoracoscopic procedure.
We reported significant increase of soluble TLR2 molecule in pleural fluid effusion during talc pleurodesis from preoperative value.
This increase was approximately 8-fold in the interval of 24 hours.
The changes on granulocyte population were quite different.
The mean fluorescent intensity of membrane TLR2 molecule examined by flow cytometry on granulocyte population significantly decreased after talc exposure with comparison to prethoracoscopic density.
To estimate the prognostic value of TLR2 expression in pleural fluid patients were retrospectively classified into either prognostically favourable or unfavourable groups.
Our results proved that patients with favourable prognosis had more than 3-fold higher soluble TLR2 level in pleural fluid early, 2 hours after talc pleurodesis intervention.
American Psychological Association (APA)
Jankovicova, Karolina& Kondelkova, Katerina& Habal, Petr& Andrys, Ctirad& Krejsek, Jan& Mandak, Jiri. 2012. TLR2 in Pleural Fluid Is Modulated by Talc Particles during Pleurodesis. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-994349
Modern Language Association (MLA)
Jankovicova, Karolina…[et al.]. TLR2 in Pleural Fluid Is Modulated by Talc Particles during Pleurodesis. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-994349
American Medical Association (AMA)
Jankovicova, Karolina& Kondelkova, Katerina& Habal, Petr& Andrys, Ctirad& Krejsek, Jan& Mandak, Jiri. TLR2 in Pleural Fluid Is Modulated by Talc Particles during Pleurodesis. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-994349
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994349