Mechanisms behind Functional Avidity Maturation in T Cells
Joint Authors
Geisler, Carsten
von Essen, Marina Rode
Kongsbak, Martin
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
During an immune response antigen-primed B-cells increase their antigen responsiveness by affinity maturation mediated by somatic hypermutation of the genes encoding the antigen-specific B-cell receptor (BCR) and by selection of higher-affinity B cell clones.
Unlike the BCR, the T-cell receptor (TCR) cannot undergo affinity maturation.
Nevertheless, antigen-primed T cells significantly increase their antigen responsiveness compared to antigen-inexperienced (naïve) T cells in a process called functional avidity maturation.
This paper covers studies that describe differences in T-cell antigen responsiveness during T-cell differentiation along with examples of the mechanisms behind functional avidity maturation in T cells.
American Psychological Association (APA)
von Essen, Marina Rode& Kongsbak, Martin& Geisler, Carsten. 2012. Mechanisms behind Functional Avidity Maturation in T Cells. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-994351
Modern Language Association (MLA)
von Essen, Marina Rode…[et al.]. Mechanisms behind Functional Avidity Maturation in T Cells. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-994351
American Medical Association (AMA)
von Essen, Marina Rode& Kongsbak, Martin& Geisler, Carsten. Mechanisms behind Functional Avidity Maturation in T Cells. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-994351
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994351