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Inflammatory Cytokines in Maternal Circulation and Placenta of Chromosomally Abnormal First Trimester Miscarriages
Joint Authors
Jauniaux, Eric
Muttukrishna, Shanthi
Calleja-Agius, Jean
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-29
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The impact of abnormal placental karyotype on the inflammatory response within the villous tissue and peripheral circulation of women with miscarriage was evaluated.
Villous (n=38) and venous blood samples (n=26) were obtained from women with missed miscarriage.
Tissue chromosome analysis indicated 23 abnormal and 15 normal karyotypes.
Concentration of tumour necrosis factor alpha (TNFα), TNF-R1 and TNF-R2, and interleukin (IL)-10 were measured using flowcytometric bead array in fresh villous homogenate, cultured villous extracts, culture medium, maternal whole blood, and plasma.
Plasma TNFα/IL-10 ratios were significantly (P<0.05) lower in miscarriages with abnormal karyotype.
In the abnormal karyotype group, there were significantly higher levels of TNFα (P<0.01), IL-10 (P<0.01), TNF-R1 (P<0.001), and TNF-R2 (P<0.001) in the villous extracts and culture-conditioned medium compared to normal karyotype group.
In miscarriage with abnormal karyotype, there is an exacerbated placental inflammatory response, in contrast to miscarriage of normal karyotype where maternal systemic response is increased.
American Psychological Association (APA)
Calleja-Agius, Jean& Jauniaux, Eric& Muttukrishna, Shanthi. 2011. Inflammatory Cytokines in Maternal Circulation and Placenta of Chromosomally Abnormal First Trimester Miscarriages. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-994354
Modern Language Association (MLA)
Calleja-Agius, Jean…[et al.]. Inflammatory Cytokines in Maternal Circulation and Placenta of Chromosomally Abnormal First Trimester Miscarriages. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-994354
American Medical Association (AMA)
Calleja-Agius, Jean& Jauniaux, Eric& Muttukrishna, Shanthi. Inflammatory Cytokines in Maternal Circulation and Placenta of Chromosomally Abnormal First Trimester Miscarriages. Journal of Immunology Research. 2011. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-994354
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994354