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Cellular and Humoral Mechanisms Involved in the Control of Tuberculosis
Joint Authors
Granados, Julio
Yunis, Edmond J.
Santos-Mendoza, Teresa
Rodriguez-Reyna, Tatiana S.
Torres-García, Diana
Zuñiga, Joaquin
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-17
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Mycobacterium tuberculosis (Mtb) infection is a major international public health problem.
One-third of the world's population is thought to have latent tuberculosis, a condition where individuals are infected by the intracellular bacteria without active disease but are at risk for reactivation, if their immune system fails.
Here, we discuss the role of nonspecific inflammatory responses mediated by cytokines and chemokines induced by interaction of innate receptors expressed in macrophages and dendritic cells (DCs).
We also review current information regarding the importance of several cytokines including IL-17/IL-23 in the development of protective cellular and antibody-mediated protective responses against Mtb and their influence in containment of the infection.
Finally, in this paper, emphasis is placed on the mechanisms of failure of Mtb control, including the immune dysregulation induced by the treatment with biological drugs in different autoimmune diseases.
Further functional studies, focused on the mechanisms involved in the early host-Mtb interactions and the interplay between host innate and acquired immunity against Mtb, may be helpful to improve the understanding of protective responses in the lung and in the development of novel therapeutic and prophylactic tools in TB.
American Psychological Association (APA)
Zuñiga, Joaquin& Torres-García, Diana& Santos-Mendoza, Teresa& Rodriguez-Reyna, Tatiana S.& Granados, Julio& Yunis, Edmond J.. 2012. Cellular and Humoral Mechanisms Involved in the Control of Tuberculosis. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-18.
https://search.emarefa.net/detail/BIM-994364
Modern Language Association (MLA)
Zuñiga, Joaquin…[et al.]. Cellular and Humoral Mechanisms Involved in the Control of Tuberculosis. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-18.
https://search.emarefa.net/detail/BIM-994364
American Medical Association (AMA)
Zuñiga, Joaquin& Torres-García, Diana& Santos-Mendoza, Teresa& Rodriguez-Reyna, Tatiana S.& Granados, Julio& Yunis, Edmond J.. Cellular and Humoral Mechanisms Involved in the Control of Tuberculosis. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-18.
https://search.emarefa.net/detail/BIM-994364
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994364