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Expression of the Autoimmune Regulator Gene and Its Relevance to the Mechanisms of Central and Peripheral Tolerance
Author
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-22
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The autoimmune polyendocrine syndrome type 1 (APS-1) is a monogenic disease due to pathogenic variants occurring in the autoimmune regulator (AIRE) gene.
Its related protein, AIRE, activates the transcription of genes encoding for tissue-specific antigens (TsAgs) in a subset of medullary thymic epithelial cells: the presentation of TsAgs to the maturating thymocytes induces the apoptosis of the autoreactive clones and constitutes the main form of central tolerance.
Dysregulation of thymic AIRE expression in genetically transmitted and acquired diseases other than APS-1 may contribute to further forms of autoimmunity.
As AIRE and its murine homolog are also expressed in the secondary lymphoid organs, the extent and relevance of AIRE participation in the mechanisms of peripheral tolerance need to be thoroughly defined.
American Psychological Association (APA)
Perniola, Roberto. 2012. Expression of the Autoimmune Regulator Gene and Its Relevance to the Mechanisms of Central and Peripheral Tolerance. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-994370
Modern Language Association (MLA)
Perniola, Roberto. Expression of the Autoimmune Regulator Gene and Its Relevance to the Mechanisms of Central and Peripheral Tolerance. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-994370
American Medical Association (AMA)
Perniola, Roberto. Expression of the Autoimmune Regulator Gene and Its Relevance to the Mechanisms of Central and Peripheral Tolerance. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-994370
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994370