The Impact of Osteopontin Gene Variations on Multiple Sclerosis Development and Progression
Joint Authors
Guerini, Franca
Dianzani, Umberto
Comi, Cristoforo
Orilieri, Elisabetta
Chiocchetti, Annalisa
Scarpini, Elio
Leone, Maurizio
D’Alfonso, Sandra
Cantello, Roberto
Caputo, Domenico
Galimberti, Daniela
Cappellano, Giuseppe
Barizzone, Nadia
Perla, Franco
Ghezzi, Laura
Buttini, Sara
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-10
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Osteopontin is a proinflammatory molecule, modulating TH1 and TH17 responses.
Several reports suggest its involvement in multiple sclerosis (MS) pathogenesis.
We previously reported that OPN gene variations at the 3′ end are a predisposing factor for MS development and evolution.
In this paper, we extended our analysis to a gene variation at the 5′ end on the -156G>GG single nucleotide polymorphism (SNP) and replicated our previous findings at the 3′ end on the +1239A>C SNP.
We found that only +1239A>C SNP displayed a statistically significant association with MS development, but both +1239A>C and -156G>GG had an influence on MS progression, since patients homozygous for both +1239A and −156GG alleles displayed slower progression of disability and slower switch to secondary progression than those carrying +1239C and/or −156G and those homozygous for +1239A only.
Moreover, patients homozygous for +1239A also displayed a significantly lower relapse rate than those carrying +1239C, which is in line with the established role of OPN in MS relapses.
American Psychological Association (APA)
Comi, Cristoforo& Cappellano, Giuseppe& Chiocchetti, Annalisa& Orilieri, Elisabetta& Buttini, Sara& Ghezzi, Laura…[et al.]. 2012. The Impact of Osteopontin Gene Variations on Multiple Sclerosis Development and Progression. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-994372
Modern Language Association (MLA)
Comi, Cristoforo…[et al.]. The Impact of Osteopontin Gene Variations on Multiple Sclerosis Development and Progression. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-994372
American Medical Association (AMA)
Comi, Cristoforo& Cappellano, Giuseppe& Chiocchetti, Annalisa& Orilieri, Elisabetta& Buttini, Sara& Ghezzi, Laura…[et al.]. The Impact of Osteopontin Gene Variations on Multiple Sclerosis Development and Progression. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-994372
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994372