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Dietary Supplementation with Omega-3-PUFA-Rich Fish Oil Reduces Signs of Food Allergy in Ovalbumin-Sensitized Mice
Joint Authors
Ferreira, Adaliene Versiani Matos
Perez, Denise Alves
de Matos, Olívia Gonçalves
Menezes, Gustavo Batista
Alvarenga, Débora Moreira
Alvarez-Leite, Jacqueline
Amaral, Sylvia Stella
Cara, Denise Carmona
Pereira da Silva, Pedro Elias Marques
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
We investigated the effect of dietary supplementation with n-3 PUFA (fish oil source) in an experimental model of food allergy.
Mice were sensitized (allergic group) or not (nonallergic group) with OVA and were fed with OVA diet to induce allergy signals.
Mice were fed with regular diet in which 7% of lipid content was provided by soybean (5% of n-3 PUFA) or fish (25% of n-3 PUFA) oil.
Allergic group mice had increased serum levels of antiovalbumin IgE and IgG1 and changes in small intestine, characterized by an increased edema, number of rolling leukocytes in microcirculation, eosinophil infiltration, mucus production, and Paneth cell degranulation, in comparison to non-allergic group.
All these inflammatory parameters were reduced in mice fed high-n-3-PUFA diet.
Our data together suggest that diet supplementation with n-3 PUFA from fish oil may consist of a valid adjuvant in food allergy treatment.
American Psychological Association (APA)
de Matos, Olívia Gonçalves& Amaral, Sylvia Stella& Pereira da Silva, Pedro Elias Marques& Perez, Denise Alves& Alvarenga, Débora Moreira& Ferreira, Adaliene Versiani Matos…[et al.]. 2011. Dietary Supplementation with Omega-3-PUFA-Rich Fish Oil Reduces Signs of Food Allergy in Ovalbumin-Sensitized Mice. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-994376
Modern Language Association (MLA)
de Matos, Olívia Gonçalves…[et al.]. Dietary Supplementation with Omega-3-PUFA-Rich Fish Oil Reduces Signs of Food Allergy in Ovalbumin-Sensitized Mice. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-994376
American Medical Association (AMA)
de Matos, Olívia Gonçalves& Amaral, Sylvia Stella& Pereira da Silva, Pedro Elias Marques& Perez, Denise Alves& Alvarenga, Débora Moreira& Ferreira, Adaliene Versiani Matos…[et al.]. Dietary Supplementation with Omega-3-PUFA-Rich Fish Oil Reduces Signs of Food Allergy in Ovalbumin-Sensitized Mice. Journal of Immunology Research. 2011. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-994376
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994376