B-Cell-Activating Factor Affects the Occurrence of Thyroid Autoimmunity in Chronic Hepatitis C Patients Treated with Interferon Alpha
Joint Authors
Takai, Atsuko
Kikuchi, Kentaro
Hoshino, Hiromi
Hino, Kunihiko
Miyakawa, Hiroshi
Hosoya, Naomi
Kajiyama, Yusuke
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-27
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Chronic hepatitis C (CHC) patients frequently suffer from thyroid disorders during interferon therapy.
However, the mechanism remains unclear.
In this study, we investigated the association between serum B-cell-activating factor belonging to the TNF family (BAFF) levels and the presence of antithyroid peroxidase antibody (anti-TPO) in CHC patients treated with pegylated interferon alpha and ribavirin combination therapy.
Six months after the therapy, anti-TPO antibody was detected in 10 (males, 1; females, 9) of 50 patients.
The mean age of these patients was higher than that of the anti-TPO-negative patients (61 yr versus 55 yr).
Before treatment, the serum BAFF levels of the anti-TPO-positive patients were higher than those of the anti-TPO-negative patients.
After starting therapy, the serum BAFF levels of both the anti-TPO-positive and -negative patient groups were elevated.
Our findings suggest that the serum BAFF concentration before therapy can predict the risk of thyroid autoimmunity in elderly female patients with CHC.
American Psychological Association (APA)
Kajiyama, Yusuke& Kikuchi, Kentaro& Takai, Atsuko& Hosoya, Naomi& Hoshino, Hiromi& Hino, Kunihiko…[et al.]. 2012. B-Cell-Activating Factor Affects the Occurrence of Thyroid Autoimmunity in Chronic Hepatitis C Patients Treated with Interferon Alpha. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-994380
Modern Language Association (MLA)
Kajiyama, Yusuke…[et al.]. B-Cell-Activating Factor Affects the Occurrence of Thyroid Autoimmunity in Chronic Hepatitis C Patients Treated with Interferon Alpha. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-4.
https://search.emarefa.net/detail/BIM-994380
American Medical Association (AMA)
Kajiyama, Yusuke& Kikuchi, Kentaro& Takai, Atsuko& Hosoya, Naomi& Hoshino, Hiromi& Hino, Kunihiko…[et al.]. B-Cell-Activating Factor Affects the Occurrence of Thyroid Autoimmunity in Chronic Hepatitis C Patients Treated with Interferon Alpha. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-994380
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994380