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Association between IL17 Polymorphisms and Risk of Cervical Cancer in Chinese Women
Joint Authors
Xi, Mingrong
Song, Yaping
Zhang, Lin
Zhou, Bin
Wang, Yanyun
Duan, Ruiqi
Shi, Shaoqing
Gao, Qianqian
Quan, Yi
Wang, Kana
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-25
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Interleukin-17 (IL-17) is a proinflammatory cytokine that is associated with inflammation, autoimmune disorders, and even tumors.
Previous studies revealed that a large group of human malignant tumors have abnormally high IL-17 expression.
In the present study, we analyzed two single-nucleotide polymorphisms (SNPs) in the IL17A (rs2275913) and IL17F (rs763780) in 311 cervical cancer patients and 463 controls using TaqMan assays.
Our results indicated that the frequencies of AA genotype and A allele of rs2275913 were significantly different between the cervical cancer patients and controls (P=0.008, OR = 1.32, 95% CI, 1.07–1.62).
Stratified analyses revealed that the polymorphism of rs2275913 was also associated with positive peritumor intravascular cancer emboli and high clinical stage.
The genotype and allele frequencies of rs763780 did not show any difference between patients and controls or relate to patient clinical characteristics.
Collectively, these findings suggested that IL17 gene polymorphism rs2275913 was associated with the susceptibility as well as positive peritumor intravascular cancer emboli and high clinical stage of cervical cancer in Chinese women.
American Psychological Association (APA)
Quan, Yi& Zhou, Bin& Wang, Yanyun& Duan, Ruiqi& Wang, Kana& Gao, Qianqian…[et al.]. 2012. Association between IL17 Polymorphisms and Risk of Cervical Cancer in Chinese Women. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-994383
Modern Language Association (MLA)
Quan, Yi…[et al.]. Association between IL17 Polymorphisms and Risk of Cervical Cancer in Chinese Women. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-994383
American Medical Association (AMA)
Quan, Yi& Zhou, Bin& Wang, Yanyun& Duan, Ruiqi& Wang, Kana& Gao, Qianqian…[et al.]. Association between IL17 Polymorphisms and Risk of Cervical Cancer in Chinese Women. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-994383
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994383