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Correlation of Circulating Glucocorticoid-Induced TNFR-Related Protein Ligand Levels with Disease Activity in Patients with Systemic Lupus Erythematosus
Joint Authors
Tan, Wenfeng
Zhang, Xiaojun
Wang, Hong
Gu, Lei
Xu, Lingxiao
Zhang, Miaojia
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-04
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The aim of this paper is to investigate the correlation of glucocorticoid-induced tumor necrosis factor receptor- (TNFR-) related protein ligand (GITRL) with disease activity and organ involvement in patients with systemic lupus erythematosus (SLE).
Serum GITRL levels were measured in 58 patients with SLE and 30 healthy controls matched for age and sex.
Patients were assessed for clinical and laboratory variables.
Correlations of serum GITRL levels with SLEDAI, laboratory values, and clinical manifestations were assessed.
Serum GITRL levels were determined by ELISA.
Serum GITRL levels were markedly increased in patients with SLE compared with healthy controls (mean 401.3 ng/mL and 36.59 ng/mL, resp.; P<0.0001).
SLE patients with active disease showed higher serum GITRL levels compared to those with inactive disease (mean 403.3 ng/mL and 136.3 ng/mL, resp; P=0.0043) as well as normal controls (36.59 ng/mL; P<0.0001).
Serum GITRL levels were positively correlated with SLEDAI, titers of anti-dsDNA antibody, erythrocyte sedimentation rate (ESR), and IgM and negatively correlated with complement3 (C3).
Serum GITRL levels were higher in SLE patients with renal involvement and vasculitis compared with patients without the above-mentioned manifestations.
American Psychological Association (APA)
Gu, Lei& Xu, Lingxiao& Zhang, Xiaojun& Tan, Wenfeng& Wang, Hong& Zhang, Miaojia. 2012. Correlation of Circulating Glucocorticoid-Induced TNFR-Related Protein Ligand Levels with Disease Activity in Patients with Systemic Lupus Erythematosus. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-994387
Modern Language Association (MLA)
Gu, Lei…[et al.]. Correlation of Circulating Glucocorticoid-Induced TNFR-Related Protein Ligand Levels with Disease Activity in Patients with Systemic Lupus Erythematosus. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-994387
American Medical Association (AMA)
Gu, Lei& Xu, Lingxiao& Zhang, Xiaojun& Tan, Wenfeng& Wang, Hong& Zhang, Miaojia. Correlation of Circulating Glucocorticoid-Induced TNFR-Related Protein Ligand Levels with Disease Activity in Patients with Systemic Lupus Erythematosus. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-994387
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994387