Perinatal Gene-Gene and Gene-Environment Interactions on IgE Production and Asthma Development
Joint Authors
Chen, Rong-Fu
Chang, Jen-Chieh
Liu, Chieh-An
Wang, Lin
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Atopic asthma is a complex disease associated with IgE-mediated immune reactions.
Numerous genome-wide studies identified more than 100 genes in 22 chromosomes associated with atopic asthma, and different genetic backgrounds in different environments could modulate susceptibility to atopic asthma.
Current knowledge emphasizes the effect of tobacco smoke on the development of childhood asthma.
This suggests that asthma, although heritable, is significantly affected by gene-gene and gene-environment interactions.
Evidence has recently shown that molecular mechanism of a complex disease may be limited to not only DNA sequence differences, but also gene-environmental interactions for epigenetic difference.
This paper reviews and summarizes how gene-gene and gene-environment interactions affect IgE production and the development of atopic asthma in prenatal and childhood stages.
Based on the mechanisms responsible for perinatal gene-environment interactions on IgE production and development of asthma, we formulate several potential strategies to prevent the development of asthma in the perinatal stage.
American Psychological Association (APA)
Chang, Jen-Chieh& Wang, Lin& Chen, Rong-Fu& Liu, Chieh-An. 2012. Perinatal Gene-Gene and Gene-Environment Interactions on IgE Production and Asthma Development. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-994389
Modern Language Association (MLA)
Chang, Jen-Chieh…[et al.]. Perinatal Gene-Gene and Gene-Environment Interactions on IgE Production and Asthma Development. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-994389
American Medical Association (AMA)
Chang, Jen-Chieh& Wang, Lin& Chen, Rong-Fu& Liu, Chieh-An. Perinatal Gene-Gene and Gene-Environment Interactions on IgE Production and Asthma Development. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-994389
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994389