Persistence of Diarrheal Pathogens Is Associated with Continued Recruitment of Plasmablasts in the Circulation
Author
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Intestinal antigen encounter leads to recirculation of antigen-specific plasmablasts via lymphatics and blood back to the intestine.
Investigating these gut-originating cells in blood provides a less invasive tool for studying intestinal immune responses, with the limitation that the cells disappear from the circulation in two weeks.
No data exist on situations where pathogens persist in the intestine.
Patients with Salmonella, Yersinia, or Campylobacter gastroenteritis and volunteers receiving an oral typhoid vaccine were assayed for plasmablasts specific to each subject's own pathogen/antigen weekly until the response faded.
In vaccinees, plasmablasts disappeared in two weeks.
In gastroenteritis, the response faded 2-3 and 3–7 weeks after the last positive Salmonella or Yersinia stool culture.
Even in symptomless patients, pathogens persisting in the intestine keep seeding plasmablasts into the circulation.
Assaying these cells might offer a powerful tool for research into diseases in which persisting microbes have a potential pathogenetic significance.
American Psychological Association (APA)
Kantele, Anu. 2012. Persistence of Diarrheal Pathogens Is Associated with Continued Recruitment of Plasmablasts in the Circulation. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-994392
Modern Language Association (MLA)
Kantele, Anu. Persistence of Diarrheal Pathogens Is Associated with Continued Recruitment of Plasmablasts in the Circulation. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-994392
American Medical Association (AMA)
Kantele, Anu. Persistence of Diarrheal Pathogens Is Associated with Continued Recruitment of Plasmablasts in the Circulation. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-994392
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994392