![](/images/graphics-bg.png)
New Platform Technology for Comprehensive Serological Diagnostics of Autoimmune Diseases
Joint Authors
Anderer, Ursula
Rödiger, Stefan
Willitzki, Annika
Bogdanos, Dimitrios P.
Reinhold, Dirk
Peters, Vanessa
Sack, Ulrich
Roggenbuck, Dirk
Conrad, Karsten
Hiemann, Rico
Schierack, Peter
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Antibody assessment is an essential part in the serological diagnosis of autoimmune diseases.
However, different diagnostic strategies have been proposed for the work up of sera in particular from patients with systemic autoimmune rheumatic disease (SARD).
In general, screening for SARD-associated antibodies by indirect immunofluorescence (IIF) is followed by confirmatory testing covering different assay techniques.
Due to lacking automation, standardization, modern data management, and human bias in IIF screening, this two-stage approach has recently been challenged by multiplex techniques particularly in laboratories with high workload.
However, detection of antinuclear antibodies by IIF is still recommended to be the gold standard method for antibody screening in sera from patients with suspected SARD.
To address the limitations of IIF and to meet the demand for cost-efficient autoantibody screening, automated IIF methods employing novel pattern recognition algorithms for image analysis have been introduced recently.
In this respect, the AKLIDES technology has been the first commercially available platform for automated interpretation of cell-based IIF testing and provides multiplexing by addressable microbead immunoassays for confirmatory testing.
This paper gives an overview of recently published studies demonstrating the advantages of this new technology for SARD serology.
American Psychological Association (APA)
Willitzki, Annika& Hiemann, Rico& Peters, Vanessa& Sack, Ulrich& Schierack, Peter& Rödiger, Stefan…[et al.]. 2012. New Platform Technology for Comprehensive Serological Diagnostics of Autoimmune Diseases. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-994394
Modern Language Association (MLA)
Willitzki, Annika…[et al.]. New Platform Technology for Comprehensive Serological Diagnostics of Autoimmune Diseases. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-994394
American Medical Association (AMA)
Willitzki, Annika& Hiemann, Rico& Peters, Vanessa& Sack, Ulrich& Schierack, Peter& Rödiger, Stefan…[et al.]. New Platform Technology for Comprehensive Serological Diagnostics of Autoimmune Diseases. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-994394
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994394