Indirect Effects of Oral Tolerance Inhibit Pulmonary Granulomas to Schistosoma mansoni Eggs
Joint Authors
Costa, Raquel Alves
Vaz, Nelson Monteiro
Carvalho, Cláudia Rocha
Azevedo, Geraldo Magela
Resende, Mariana Araujo
Rodrigues, Claudiney Melquiades
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-13
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Parenteral injection of tolerated proteins into orally tolerant mice inhibits the initiation of immunological responses to unrelated proteins and blocks severe chronic inflammatory reactions of immunological origin, such as autoimmune reactions.
This inhibitory effect which we have called “indirect effects of oral tolerance” is also known as “bystander suppression.” Herein, we show that i.p.
injection of OVA + Al(OH)3 minutes before i.v.
injection of Schistosoma mansoni eggs into OVA tolerant mice blocked the increase of pulmonary granulomas.
In addition, the expression of ICAM-1 in lung parenchyma in areas outside the granulomas of OVA-orally tolerant mice was significantly reduced.
However, at day 18 after granuloma induction there was no difference in immunofluorescency intensity to CD3, CD4, F4/80, and α-SMA per granuloma area of tolerant and control groups.
Reduction of granulomas by reexposure to orally tolerated proteins was not correlated with a shift in Th-1/Th-2 cytokines in serum or lung tissue extract.
American Psychological Association (APA)
Azevedo, Geraldo Magela& Costa, Raquel Alves& Resende, Mariana Araujo& Rodrigues, Claudiney Melquiades& Vaz, Nelson Monteiro& Carvalho, Cláudia Rocha. 2011. Indirect Effects of Oral Tolerance Inhibit Pulmonary Granulomas to Schistosoma mansoni Eggs. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-994398
Modern Language Association (MLA)
Azevedo, Geraldo Magela…[et al.]. Indirect Effects of Oral Tolerance Inhibit Pulmonary Granulomas to Schistosoma mansoni Eggs. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-994398
American Medical Association (AMA)
Azevedo, Geraldo Magela& Costa, Raquel Alves& Resende, Mariana Araujo& Rodrigues, Claudiney Melquiades& Vaz, Nelson Monteiro& Carvalho, Cláudia Rocha. Indirect Effects of Oral Tolerance Inhibit Pulmonary Granulomas to Schistosoma mansoni Eggs. Journal of Immunology Research. 2011. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-994398
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994398