Adaptive and Innate Immune Responsiveness to Borrelia burgdorferi sensu lato in Exposed Asymptomatic Children and Children with Previous Clinical Lyme Borreliosis
Joint Authors
Ekerfelt, Christina
Ernerudh, Jan
Forsberg, Pia
Skogman, Barbro H.
Bergström, Sven
Hellberg, Sandra
Jenmalm, Maria C.
Ludvigsson, Johnny
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Why some individuals develop clinical manifestations in Lyme borreliosis (LB) while others remain asymptomatic is largely unknown.
Therefore, we wanted to investigate adaptive and innate immune responsiveness to Borrelia burgdorferi sensu lato in exposed Borrelia-antibody-positive asymptomatic children (n=20), children with previous clinical LB (n=24), and controls (n=20).
Blood samples were analyzed for Borrelia-specific interferon (IFN)-γ, interleukin (IL)-4, and IL-17 secretion by ELISPOT and Borrelia-induced IL-1β, IL-6, IL-10, IL-12(p70), and tumor necrosis factor (TNF) secretion by Luminex.
We found no significant differences in cytokine secretion between groups, but a tendency towards an increased spontaneous secretion of IL-6 was found among children with previous clinical LB.
In conclusion, the adaptive or innate immune responsiveness to Borrelia burgdorferi sensu lato was similar in Borrelia-exposed asymptomatic children and children with previous clinical LB.
Thus, the immunological mechanisms of importance for eradicating the spirochete effectively without developing clinical manifestations of LB remain unknown.
American Psychological Association (APA)
Skogman, Barbro H.& Hellberg, Sandra& Ekerfelt, Christina& Jenmalm, Maria C.& Forsberg, Pia& Ludvigsson, Johnny…[et al.]. 2011. Adaptive and Innate Immune Responsiveness to Borrelia burgdorferi sensu lato in Exposed Asymptomatic Children and Children with Previous Clinical Lyme Borreliosis. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-994399
Modern Language Association (MLA)
Skogman, Barbro H.…[et al.]. Adaptive and Innate Immune Responsiveness to Borrelia burgdorferi sensu lato in Exposed Asymptomatic Children and Children with Previous Clinical Lyme Borreliosis. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-994399
American Medical Association (AMA)
Skogman, Barbro H.& Hellberg, Sandra& Ekerfelt, Christina& Jenmalm, Maria C.& Forsberg, Pia& Ludvigsson, Johnny…[et al.]. Adaptive and Innate Immune Responsiveness to Borrelia burgdorferi sensu lato in Exposed Asymptomatic Children and Children with Previous Clinical Lyme Borreliosis. Journal of Immunology Research. 2011. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-994399
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994399