The Place of Immunotherapy in the Management of HCV-Induced Vasculitis: An Update
Joint Authors
Jourde-Chiche, Noémie
Kaplanski, Gilles
Bataille, Stanislas
Chiche, Laurent
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Patients with chronic hepatitis C virus (HCV) can develop systemic cryoglobulinemic vasculitis.
Combination of pegylated-interferon α and ribavirin is the first-line treatment of this condition.
However, in case of severe or life-threatening manifestations, absence of a virological response, or autonomized vasculitis, immunotherapy (alone or in addition to the antiviral regimen) is necessary.
Rituximab is to date the only biologic with a sufficient level of evidence to support its use in this indication.
Several studies have demonstrated that rituximab is highly effective when cryoglobulinaemic vasculitis is refractory to antiviral regimen, that association of rituximab with antiviral regimen may induce a better and faster clinical remission, and, recently, that rituximab is more efficient than traditional immunosuppressive treatments.
Some issues with regard to the optimal dose of rituximab or its use as maintenance treatment remain unsolved.
Interestingly, in balance with this anti-inflammatory strategy, a recent pilot study reported the significant expansion of circulating regulatory T lymphocytes with concomitant clinical improvement in patients with refractory HCV-induced cryoglobulinaemic vasculitis using low dose of subcutaneous interleukin-2.
This paper provides an updated overview on the place of immunotherapy, especially biologics, in the management of HCV-induced cryoglobulinaemic vasculitis.
American Psychological Association (APA)
Chiche, Laurent& Bataille, Stanislas& Kaplanski, Gilles& Jourde-Chiche, Noémie. 2012. The Place of Immunotherapy in the Management of HCV-Induced Vasculitis: An Update. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-994404
Modern Language Association (MLA)
Chiche, Laurent…[et al.]. The Place of Immunotherapy in the Management of HCV-Induced Vasculitis: An Update. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-994404
American Medical Association (AMA)
Chiche, Laurent& Bataille, Stanislas& Kaplanski, Gilles& Jourde-Chiche, Noémie. The Place of Immunotherapy in the Management of HCV-Induced Vasculitis: An Update. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-994404
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994404