Thr92Ala Polymorphism of Human Type 2 Deiodinase Gene (hD2) Affects the Development of Graves' Disease, Treatment Efficiency, and Rate of Remission
Joint Authors
Olga, Freylihman
Anna, Kostareva
Babenko, A. Y.
Vladislav, Solncev
Daria, Popkova
Elena, Grineva
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-12
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Clinical symptoms vary in thyrotoxicosis, and severity of these depends on many factors.
Over the last years, impact of genetic factors upon the development and clinical significance of thyrotoxic symptoms became evident.
It is known that a production of T3 in various tissues is limited by deiodinase 2 (D2).
Recent studies revealed that certain single nucleotide polymorphisms (including threonine (Thr) to alanine (Ala) replacement in D2 gene codon 92, D2 Thr92Ala) affect T3 levels in tissues and in serum.
Individuals with Ala92Ala genotype have lower D2 activity in tissues, compared with that in individuals with other genotypes.
In our study, we have assessed an association of D2 Thr92Ala polymorphism with (1) frequency of disease development, (2) severity of clinical symptoms of thyrotoxicosis, and (3) rate of remissions, in Graves' disease patients.
American Psychological Association (APA)
Babenko, A. Y.& Daria, Popkova& Olga, Freylihman& Vladislav, Solncev& Anna, Kostareva& Elena, Grineva. 2012. Thr92Ala Polymorphism of Human Type 2 Deiodinase Gene (hD2) Affects the Development of Graves' Disease, Treatment Efficiency, and Rate of Remission. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-994406
Modern Language Association (MLA)
Babenko, A. Y.…[et al.]. Thr92Ala Polymorphism of Human Type 2 Deiodinase Gene (hD2) Affects the Development of Graves' Disease, Treatment Efficiency, and Rate of Remission. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-994406
American Medical Association (AMA)
Babenko, A. Y.& Daria, Popkova& Olga, Freylihman& Vladislav, Solncev& Anna, Kostareva& Elena, Grineva. Thr92Ala Polymorphism of Human Type 2 Deiodinase Gene (hD2) Affects the Development of Graves' Disease, Treatment Efficiency, and Rate of Remission. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-994406
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994406