Carbonic Anhydrases III and IV Autoantibodies in Rheumatoid Arthritis, Systemic Lupus Erythematosus, Diabetes, Hypertensive Renal Disease, and Heart Failure
Joint Authors
Wang, Peichang
Pi, Langan
Huang, Jianjun
Liu, Chengeng
Wei, Yue
Wang, Jianmin
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-16
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
In the present study, the CA III and IV autoantibodies, CA activity, antioxidant enzymes and cytokines in rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), diabetes, hypertensive renal disease, and heart failure were investigated.
The anti-CA III antibody titers in patients with RA, SLE, and type 1 diabetes (T1D) were significantly higher than that in control groups (P<0.05).
The anti-CA IV antibody titers in patients with RA, SLE, type 1 diabetic nephropathy (T1DN), and heart failure were significantly higher than that in control groups (P<0.05) while anti-CA IV antibody could suppress the total CA activity.
The SOD and GPx levels in patients with RA, SLE, and T1DN were significantly lower than that in control groups (P<0.05).
IL-6, IL-17, IFN-γ, and TNF-α levels were significantly higher in SLE group compared with the control group (P<0.05).
Weak but significant correlations were found between anti-CA III antibodies and ESR in RA (r=0.403, P=0.013) and SLE patients (r=0.397, P=0.007).
These results suggested that the generation of CA III and IV autoantibodies, antioxidant enzymes, and cytokines might influence each other and CA autoantibodies might affect the normal physiology function of CA.
American Psychological Association (APA)
Liu, Chengeng& Wei, Yue& Wang, Jianmin& Pi, Langan& Huang, Jianjun& Wang, Peichang. 2012. Carbonic Anhydrases III and IV Autoantibodies in Rheumatoid Arthritis, Systemic Lupus Erythematosus, Diabetes, Hypertensive Renal Disease, and Heart Failure. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-994411
Modern Language Association (MLA)
Liu, Chengeng…[et al.]. Carbonic Anhydrases III and IV Autoantibodies in Rheumatoid Arthritis, Systemic Lupus Erythematosus, Diabetes, Hypertensive Renal Disease, and Heart Failure. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-994411
American Medical Association (AMA)
Liu, Chengeng& Wei, Yue& Wang, Jianmin& Pi, Langan& Huang, Jianjun& Wang, Peichang. Carbonic Anhydrases III and IV Autoantibodies in Rheumatoid Arthritis, Systemic Lupus Erythematosus, Diabetes, Hypertensive Renal Disease, and Heart Failure. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-994411
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994411