Clinical Relevance of Autoantibodies in Patients with Autoimmune Bullous Dermatosis
Joint Authors
Husz, Sándor
Kiss, Mária
Mihályi, Lilla
Kemény, Lajos
Dobozy, Attila
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The authors present their experience related to the diagnosis, treatment, and followup of 431 patients with bullous pemphigoid, 14 patients with juvenile bullous pemphigoid, and 273 patients with pemphigus.
The detection of autoantibodies plays an outstanding role in the diagnosis and differential diagnosis.
Paraneoplastic pemphigoid is suggested to be a distinct entity from the group of bullous pemphigoid in view of the linear C3 deposits along the basement membrane of the perilesional skin and the “ladder” configuration of autoantibodies demonstrated by western blot analysis.
It is proposed that IgA pemphigoid should be differentiated from the linear IgA dermatoses.
Immunosuppressive therapy is recommended in which the maintenance dose of corticosteroid is administered every second day, thereby reducing the side effects of the corticosteroids.
Following the detection of IgA antibodies (IgA pemphigoid, linear IgA bullous dermatosis, and IgA pemphigus), diamino diphenyl sulfone (dapsone) therapy is preferred alone or in combination.
The clinical relevance of autoantibodies in patients with autoimmune bullous dermatosis is stressed.
American Psychological Association (APA)
Mihályi, Lilla& Kiss, Mária& Dobozy, Attila& Kemény, Lajos& Husz, Sándor. 2012. Clinical Relevance of Autoantibodies in Patients with Autoimmune Bullous Dermatosis. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-994415
Modern Language Association (MLA)
Mihályi, Lilla…[et al.]. Clinical Relevance of Autoantibodies in Patients with Autoimmune Bullous Dermatosis. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-994415
American Medical Association (AMA)
Mihályi, Lilla& Kiss, Mária& Dobozy, Attila& Kemény, Lajos& Husz, Sándor. Clinical Relevance of Autoantibodies in Patients with Autoimmune Bullous Dermatosis. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-994415
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994415