BPI-ANCA and Long-Term Prognosis among 46 Adult CF Patients: A Prospective 10-Year Follow-Up Study
Joint Authors
Löfdahl, Claes-Göran
Carlsson, Malin
Segelmark, Mårten
Lindberg, Ulrika
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Anti-neutrophil cytoplasmic antibodies specific for bactericidal/permeability-increasing protein (BPI-ANCA) are frequent in CF patients and mainly develop in response to infection with Pseudomonas aeruginosa.
It is not known to what extent BPI-ANCA correlates to prognosis.
Objectives.
To evaluate the prognostic value of IgA-BPI-ANCA, measured at the beginning of the study, for transplantation-free survival.
Methods.
A cohort of 46 adult, nontransplanted CF patients was generated, 1995–1998, and characterized using Leeds criteria, lung function, and IgA-BPI-ANCA levels measured by ELISA.
The cohort was followed until December 2009, using the combined endpoint of death or lung transplantation.
Results.
Lung function and IgA-BPI-ANCA, but not Leeds criteria, were significantly associated with adverse outcome.
No patient with normal lung function at baseline reached endpoint.
Within 10 years 8/11 with high BPI-ANCA reached an endpoint compared to 3/17 ANCA-negative patients.
A similar result was seen within the Leeds I group where 7 out of 9 BPI-ANCA-positive patients reached endpoint, compared to none of the 5 patients without BPI-ANCA.
Conclusions.
IgA-BPI-ANCA is associated with adverse outcome among Pseudomonas aeruginosa infected CF patients, suggesting that BPI-ANCA is a biomarker of an unfavourable host-pathogen interaction.
American Psychological Association (APA)
Lindberg, Ulrika& Carlsson, Malin& Löfdahl, Claes-Göran& Segelmark, Mårten. 2012. BPI-ANCA and Long-Term Prognosis among 46 Adult CF Patients: A Prospective 10-Year Follow-Up Study. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-994416
Modern Language Association (MLA)
Lindberg, Ulrika…[et al.]. BPI-ANCA and Long-Term Prognosis among 46 Adult CF Patients: A Prospective 10-Year Follow-Up Study. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-994416
American Medical Association (AMA)
Lindberg, Ulrika& Carlsson, Malin& Löfdahl, Claes-Göran& Segelmark, Mårten. BPI-ANCA and Long-Term Prognosis among 46 Adult CF Patients: A Prospective 10-Year Follow-Up Study. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-994416
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994416