Interplay of Polarity Proteins and GTPases in T-Lymphocyte Function
Joint Authors
Oliaro, Jane
Russell, Sarah M.
Fung, Ivan
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Polarity refers to the asymmetric distribution of different cellular components within a cell and is central to many cell functions.
In T-cells, polarity regulates the activation, migration, and effector function of cytotoxic T-cells (CTLs) during an immune response.
The regulation of asymmetric cell division by polarity proteins may also dictate CTL effector and memory differentiation following antigen presentation.
Small GTPases, along with their associated polarity and adaptor proteins, are critical for mediating the polarity changes necessary for T-cell activation and function, and in turn, are regulated by guanine exchange factors (GEFS) and GTPase activating proteins (GAPS).
For example, a novel GEF, dedicator of cytokinesis 8 (DOCK8) was recently identified as a regulator of immune cell function and mutations in DOCK8 have been detected in patients with severe combined immunodeficiency.
Both B and T-cells from DOCK8 mutant mice form defective immunological synapses and have abnormal functions, in addition to impaired immune memory development.
This paper will discuss the interplay between polarity proteins and GTPases, and their role in T-cell function.
American Psychological Association (APA)
Fung, Ivan& Russell, Sarah M.& Oliaro, Jane. 2012. Interplay of Polarity Proteins and GTPases in T-Lymphocyte Function. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-994425
Modern Language Association (MLA)
Fung, Ivan…[et al.]. Interplay of Polarity Proteins and GTPases in T-Lymphocyte Function. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-994425
American Medical Association (AMA)
Fung, Ivan& Russell, Sarah M.& Oliaro, Jane. Interplay of Polarity Proteins and GTPases in T-Lymphocyte Function. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-994425
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994425