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Hematological Malignancies Escape from NK Cell Innate Immune Surveillance: Mechanisms and Therapeutic Implications
Joint Authors
Sanchez, Carole
Le Treut, Thérèse
Baier, Céline
Farnault, Laure
Costello, Régis T.
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Hematological malignancies treatment improved over the last years resulting in increased achievement of complete or partial remission, but unfortunately high relapse rates are still observed.
Therefore, sustainment of long-term remission is crucial.
Immune system has a key role in tumor surveillance.
Natural killer (NK) cells, at the frontier of innate and adaptive immune system, have a central role in tumor cells surveillance as demonstrated in the setting of allogenic stem cell transplantation.
Nevertheless, tumor cells develop various mechanisms to escape from NK cells innate immune pressure.
Abnormal NK cytolytic functions have been described in nearly all hematological malignancies.
We present here various mechanisms involved in the escape of hematological malignancies from NK cells surveillance: NK cells quantitative deficiency and NK cell qualitative deficiency by increased inhibition signaling or decreased activating stimuli.
A challenge of immunotherapy is to restore an efficient antitumor response.
A combination of classical therapy plus immune modulation strategies will soon become a standard of care for hematological malignancies.
American Psychological Association (APA)
Farnault, Laure& Sanchez, Carole& Baier, Céline& Le Treut, Thérèse& Costello, Régis T.. 2012. Hematological Malignancies Escape from NK Cell Innate Immune Surveillance: Mechanisms and Therapeutic Implications. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-994426
Modern Language Association (MLA)
Farnault, Laure…[et al.]. Hematological Malignancies Escape from NK Cell Innate Immune Surveillance: Mechanisms and Therapeutic Implications. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-994426
American Medical Association (AMA)
Farnault, Laure& Sanchez, Carole& Baier, Céline& Le Treut, Thérèse& Costello, Régis T.. Hematological Malignancies Escape from NK Cell Innate Immune Surveillance: Mechanisms and Therapeutic Implications. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-994426
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994426