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Induction of Immunological Tolerance by Oral Anti-CD3
Joint Authors
Weiner, Howard L.
da Cunha, Andre Pires
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-14
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
In recent years, our knowledge about immunoregulation and autoimmunity has significantly advanced, but nontoxic and more effective treatments for different inflammatory and autoimmune diseases are still lacking.
Oral tolerance is of unique immunologic importance because it is a continuous natural immunologic event driven by exogenous antigen and is an attractive approach for treatment of these conditions.
Parenteral administration of anti-CD3 monoclonal antibody is an approved therapy for transplantation in humans and is effective in autoimmune diabetes.
Orally administered anti-CD3 monoclonal antibody is biologically active in the gut and suppresses experimental models of autoimmune diseases.
Orally delivered antibody does not have side effects including cytokine release syndromes, thus oral anti-CD3 antibody is clinically applicable for chronic therapy.
Here we review findings that identify a novel and powerful immunologic approach that is widely applicable for the treatment of human autoimmune conditions.
American Psychological Association (APA)
da Cunha, Andre Pires& Weiner, Howard L.. 2011. Induction of Immunological Tolerance by Oral Anti-CD3. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-994427
Modern Language Association (MLA)
da Cunha, Andre Pires& Weiner, Howard L.. Induction of Immunological Tolerance by Oral Anti-CD3. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-994427
American Medical Association (AMA)
da Cunha, Andre Pires& Weiner, Howard L.. Induction of Immunological Tolerance by Oral Anti-CD3. Journal of Immunology Research. 2011. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-994427
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994427