Atrioventricular Conduction Delay in Fetuses Exposed to Anti-SSARo and Anti-SSBLa Antibodies: A Magnetocardiography Study
Joint Authors
Goelz, Rangmar
Muenssinger, Jana
Wacker-Gußmann, Annette
Paulsen, Henrike
Henes, Joerg
Kiefer-Schmidt, Isabelle
Weiss, Magdalene
Preissl, Hubert
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-20
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The presence of anti-SSA/Ro and anti-SSB/La antibodies during pregnancy is associated with fetal congenital heart block (CHB), which is primarily diagnosed through fetal echocardiography.
Conclusive information about the complete electrophysiology of the fetal cardiac conducting system is still lacking.
In addition to echocardiography, fetal magnetocardiography (fMCG) can be used.
fMCG is the magnetic analogue of the fetal electrocardiogram (ECG).
Patients and Methods.
Forty-eight pregnant women were enrolled in an observational study; 16 of them tested positive for anti-SSA/Ro and anti-SSB/La antibodies.
In addition to routine fetal echocardiography, fMCG was used.
Fetal cardiac time intervals (fCTIs) were extracted from the magnetic recordings by predefined procedures.
ECGs in the neonates of the study group were performed within the first month after delivery.
Results.
The PQ segment of the fCTI was significantly prolonged in the study group (P=0.007), representing a delay of the electrical impulse in the atrioventricular (AV) node.
Other fCTIs were within normal range.
None of the anti-SSA/Ro and/or anti-SSB/La fetuses progressed to a more advanced heart block during pregnancy or after birth.
Conclusion.
The study identified a low-risk population within antibody positive mothers, where PQ segment prolongation is associated with a lack of progression of the disease.
American Psychological Association (APA)
Wacker-Gußmann, Annette& Paulsen, Henrike& Kiefer-Schmidt, Isabelle& Henes, Joerg& Muenssinger, Jana& Weiss, Magdalene…[et al.]. 2012. Atrioventricular Conduction Delay in Fetuses Exposed to Anti-SSARo and Anti-SSBLa Antibodies: A Magnetocardiography Study. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-994430
Modern Language Association (MLA)
Wacker-Gußmann, Annette…[et al.]. Atrioventricular Conduction Delay in Fetuses Exposed to Anti-SSARo and Anti-SSBLa Antibodies: A Magnetocardiography Study. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-994430
American Medical Association (AMA)
Wacker-Gußmann, Annette& Paulsen, Henrike& Kiefer-Schmidt, Isabelle& Henes, Joerg& Muenssinger, Jana& Weiss, Magdalene…[et al.]. Atrioventricular Conduction Delay in Fetuses Exposed to Anti-SSARo and Anti-SSBLa Antibodies: A Magnetocardiography Study. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-994430
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994430