Toxin-Based Targeted Therapy for Malignant Brain Tumors
Joint Authors
Chandramohan, Vidyalakshmi
Sampson, John H.
Bigner, Darell D.
Pastan, Ira
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-09
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Despite advances in conventional treatment modalities for malignant brain tumors—surgery, radiotherapy, and chemotherapy—the prognosis for patients with high-grade astrocytic tumor remains dismal.
The highly heterogeneous and diffuse nature of astrocytic tumors calls for the development of novel therapies.
Advances in genomic and proteomic research indicate that treatment of brain tumor patients can be increasingly personalized according to the characteristics of the targeted tumor and its environment.
Consequently, during the last two decades, a novel class of investigative drug candidates for the treatment of central nervous system neoplasia has emerged: recombinant fusion protein conjugates armed with cytotoxic agents targeting tumor-specific antigens.
The clinical applicability of the tumor-antigen-directed cytotoxic proteins as a safe and viable therapy for brain tumors is being investigated.
Thus far, results from ongoing clinical trials are encouraging, as disease stabilization and patient survival prolongation have been observed in at least 109 cases.
This paper summarizes the major findings pertaining to treatment with the different antiglioma cytotoxins at the preclinical and clinical stages.
American Psychological Association (APA)
Chandramohan, Vidyalakshmi& Sampson, John H.& Pastan, Ira& Bigner, Darell D.. 2012. Toxin-Based Targeted Therapy for Malignant Brain Tumors. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-994443
Modern Language Association (MLA)
Chandramohan, Vidyalakshmi…[et al.]. Toxin-Based Targeted Therapy for Malignant Brain Tumors. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-15.
https://search.emarefa.net/detail/BIM-994443
American Medical Association (AMA)
Chandramohan, Vidyalakshmi& Sampson, John H.& Pastan, Ira& Bigner, Darell D.. Toxin-Based Targeted Therapy for Malignant Brain Tumors. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-994443
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994443