Genetics of Myasthenia Gravis: A Case-Control Association Study in the Hellenic Population
Joint Authors
Zagoriti, Zoi
Georgitsi, Marianthi
Ntellos, Fotios
Tzartos, Socrates J.
Patrinos, George P.
Giannakopoulou, Olga
Poulas, Konstantinos
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-03
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Myasthenia gravis (MG) is an heterogeneous autoimmune disease characterized by the production of autoantibodies against proteins of the postsynaptic membrane, in the neuromuscular junction.
The contribution of genetic factors to MG susceptibility has been evaluated through family and twin studies however, the precise genetic background of the disease remains elusive.
We conducted a case-control association study in 101 unrelated MG patients of Hellenic origin and 101 healthy volunteers in order to assess the involvement of common genetic variants in susceptibility to MG.
We focused on three candidate genes which have been clearly associated with several autoimmune diseases, aiming to investigate their potential implication in MG pathogenesis.
These are interferon regulatory factor 5 (IRF-5), TNFα-induced protein 3 (TNFAIP3), also known as A20, and interleukin-10 (IL-10), key molecules in the regulation of immune function.
A statistical trend of association (P=0.068) between IL-10 promoter single nucleotide polymorphisms (SNPs) and the subgroups of early and late-onset MG patients was revealed.
No statistically significant differences were observed in the rest of the variants examined.
As far as we are aware, this is the first worldwide attempt to address the possible association between IRF-5 and TNFAIP3 common genetic variants and the genetic basis of MG.
American Psychological Association (APA)
Zagoriti, Zoi& Georgitsi, Marianthi& Giannakopoulou, Olga& Ntellos, Fotios& Tzartos, Socrates J.& Patrinos, George P.…[et al.]. 2012. Genetics of Myasthenia Gravis: A Case-Control Association Study in the Hellenic Population. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-994452
Modern Language Association (MLA)
Zagoriti, Zoi…[et al.]. Genetics of Myasthenia Gravis: A Case-Control Association Study in the Hellenic Population. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-994452
American Medical Association (AMA)
Zagoriti, Zoi& Georgitsi, Marianthi& Giannakopoulou, Olga& Ntellos, Fotios& Tzartos, Socrates J.& Patrinos, George P.…[et al.]. Genetics of Myasthenia Gravis: A Case-Control Association Study in the Hellenic Population. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-994452
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994452