Modulation of Immunity by Antiangiogenic Molecules in Cancer
Joint Authors
Taieb, Julien
Tanchot, Corinne
Tartour, Eric
Colussi, Orianne
Marcheteau, Elie
Terme, Magali
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
In the last decades a new class of therapeutic drugs have been developed that block tumor angiogenesis.
These antiangiogenic molecules, which target VEGF or VEGFR, PDGFR, and c-kit, can act not only on endothelial cells but also on immune cells.
Some antiangiogenic molecules inhibit the development of immunosuppressive mechanisms developed by the tumors to escape the immune system (such as regulatory T cells, myeloid-derived suppressor cells, and immunosuppressive cytokines).
These immunomodulatory effects must be characterized in detail to enable a better prescription of these treatments.
In this paper we will focus on the impact of anti-angiogenic drugs on immunosuppression and their potential combination with immunotherapeutic strategies.
Interestingly, immune parameters or their modulation during treatment could serve as potential biomarkers of response or resistance to anti-angiogenic therapies.
American Psychological Association (APA)
Terme, Magali& Colussi, Orianne& Marcheteau, Elie& Tanchot, Corinne& Tartour, Eric& Taieb, Julien. 2012. Modulation of Immunity by Antiangiogenic Molecules in Cancer. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-994475
Modern Language Association (MLA)
Terme, Magali…[et al.]. Modulation of Immunity by Antiangiogenic Molecules in Cancer. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-994475
American Medical Association (AMA)
Terme, Magali& Colussi, Orianne& Marcheteau, Elie& Tanchot, Corinne& Tartour, Eric& Taieb, Julien. Modulation of Immunity by Antiangiogenic Molecules in Cancer. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-994475
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994475