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Hepatitis C Virus Infection and Mixed Cryoglobulinemia
Joint Authors
Lauletta, Gianfranco
Sansonno, Loredana
Conteduca, Vincenza
Russi, Sabino
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-10
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Hepatitis C virus (HCV) chronic infection is recognized as the major cause of mixed cryoglobulinemia (MC).
Its persistence represents a continuous stimulus for host immune system with production of circulating immune complexes (ICs), one-third of them with cryoprecipitate property.
Several factors contribute to the biological activities of ICs, many of which are not completely known.
Among them, complement factors play a crucial role in the cold-insoluble ICs-mediated vasculitis, involving primarily small blood vessels in different tissues including skin, kidney, peripheral, and central nervous system.
Liver represents the major target of HCV infection with inflammatory infiltrates, resembling secondary lymphoid follicles.
Cytokine like CXCL13 contribute to B-cell homing in intraportal lymphoid aggregates, in which B-cell clonal selection may arise.
B-cell clonal expansion starts as an antigen-driven event and expands towards indolent and malignant B-cell proliferation.
Occurrence of intrahepatic B-cell clonalities correlates with extrahepatic clinical manifestations of HCV infection.
In this context, cryoglobulinemic patients should be considered a peculiar HCV-infected population that needs a clinical multidisciplinary approach and more articulated therapeutic measures.
American Psychological Association (APA)
Lauletta, Gianfranco& Russi, Sabino& Conteduca, Vincenza& Sansonno, Loredana. 2012. Hepatitis C Virus Infection and Mixed Cryoglobulinemia. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-994482
Modern Language Association (MLA)
Lauletta, Gianfranco…[et al.]. Hepatitis C Virus Infection and Mixed Cryoglobulinemia. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-994482
American Medical Association (AMA)
Lauletta, Gianfranco& Russi, Sabino& Conteduca, Vincenza& Sansonno, Loredana. Hepatitis C Virus Infection and Mixed Cryoglobulinemia. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-994482
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994482