Complement Activation and Inhibition in Wound Healing
Joint Authors
Nibbering, Peter H.
Cazander, Gwendolyn
Jukema, Gerrolt N.
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-30
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Complement activation is needed to restore tissue injury; however, inappropriate activation of complement, as seen in chronic wounds can cause cell death and enhance inflammation, thus contributing to further injury and impaired wound healing.
Therefore, attenuation of complement activation by specific inhibitors is considered as an innovative wound care strategy.
Currently, the effects of several complement inhibitors, for example, the C3 inhibitor compstatin and several C1 and C5 inhibitors, are under investigation in patients with complement-mediated diseases.
Although (pre)clinical research into the effects of these complement inhibitors on wound healing is limited, available data indicate that reduction of complement activation can improve wound healing.
Moreover, medicine may take advantage of safe and effective agents that are produced by various microorganisms, symbionts, for example, medicinal maggots, and plants to attenuate complement activation.
To conclude, for the development of new wound care strategies, (pre)clinical studies into the roles of complement and the effects of application of complement inhibitors in wound healing are required.
American Psychological Association (APA)
Cazander, Gwendolyn& Jukema, Gerrolt N.& Nibbering, Peter H.. 2012. Complement Activation and Inhibition in Wound Healing. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-994486
Modern Language Association (MLA)
Cazander, Gwendolyn…[et al.]. Complement Activation and Inhibition in Wound Healing. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-14.
https://search.emarefa.net/detail/BIM-994486
American Medical Association (AMA)
Cazander, Gwendolyn& Jukema, Gerrolt N.& Nibbering, Peter H.. Complement Activation and Inhibition in Wound Healing. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-994486
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994486