New Insights into the Immunological Changes in IL-10-Deficient Mice during the Course of Spontaneous Inflammation in the Gut Mucosa
Joint Authors
Moreira, Thais Garcias
Lemos, Luisa
Castro-Junior, Archimedes Barbosa
Faria, Ana Maria Caetano
McCafferty, Donna-Marie
Gomes-Santos, Ana Cristina
Cara, Denise Carmona
Horta, Bernardo Coelho
Cruz, Deborah Nogueira
Guimarães, Mauro Andrade Freitas
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-01
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
IL-10 is a regulatory cytokine that plays a major role in the homeostasis of the gut and this is illustrated by the fact that IL-10−/− mice develop spontaneous colitis.
In this study, IL-10−/− mice were analyzed for immunological changes during colitis development.
We found a reduced frequency of regulatory T cells CD4+CD25+Foxp3+ and higher frequency of activated T cells in the colon that precedes the macroscopic signs of the disease.
Production of IL-17 and IFN-γ was higher in the colon.
Colitis progression culminates with the reduction of CD4+LAP+ regulatory T cells in the intestine.
Frequency of B1 cells and the secretory IgA production were both elevated.
Despite these alterations, 16-week-old IL-10−/− mice could be rendered tolerant by a continuous feeding protocol.
Our study provides detailed analysis of changes that precede colitis and it also suggests that oral tolerance could be used to design novel alternative therapies for the disease.
American Psychological Association (APA)
Gomes-Santos, Ana Cristina& Moreira, Thais Garcias& Castro-Junior, Archimedes Barbosa& Horta, Bernardo Coelho& Lemos, Luisa& Cruz, Deborah Nogueira…[et al.]. 2012. New Insights into the Immunological Changes in IL-10-Deficient Mice during the Course of Spontaneous Inflammation in the Gut Mucosa. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-994518
Modern Language Association (MLA)
Gomes-Santos, Ana Cristina…[et al.]. New Insights into the Immunological Changes in IL-10-Deficient Mice during the Course of Spontaneous Inflammation in the Gut Mucosa. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-994518
American Medical Association (AMA)
Gomes-Santos, Ana Cristina& Moreira, Thais Garcias& Castro-Junior, Archimedes Barbosa& Horta, Bernardo Coelho& Lemos, Luisa& Cruz, Deborah Nogueira…[et al.]. New Insights into the Immunological Changes in IL-10-Deficient Mice during the Course of Spontaneous Inflammation in the Gut Mucosa. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-994518
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994518