Mesangial Cell-Specific Antibodies Are Central to the Pathogenesis of Lupus Nephritis
Joint Authors
Seret, Guillaume
Youinou, Pierre
Renaudineau, Yves
Le Meur, Yannick
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Not only is nephritis a common complaint in systemic lupus erythematosus, but it is also the most life-threatening complication of the disease.
Anti-double-stranded DNA antibodies (Abs), which are found in up to 80% of these patients, might be nephritogenic per se.
That is, they may cross-react with mesangial cell (MC) surface proteins, such as alpha-actinin and annexin A2, they may cross-react with mesangial matrix protein such as laminine and fibronectin, or they may recognize chromatin material previously deposited in the glomeruli.
The consequence of the binding of anti-MC Abs may be their internalization, which results in activation and proliferation of these MCs.
In turn, these activated MCs are suspected of promoting immune complex formation by sequestering and thereby protecting chromatin from degradation.
The present paper will explain the mechanisms through which such autoAbs may initiate nephritis.
American Psychological Association (APA)
Seret, Guillaume& Le Meur, Yannick& Renaudineau, Yves& Youinou, Pierre. 2011. Mesangial Cell-Specific Antibodies Are Central to the Pathogenesis of Lupus Nephritis. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-994524
Modern Language Association (MLA)
Seret, Guillaume…[et al.]. Mesangial Cell-Specific Antibodies Are Central to the Pathogenesis of Lupus Nephritis. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-994524
American Medical Association (AMA)
Seret, Guillaume& Le Meur, Yannick& Renaudineau, Yves& Youinou, Pierre. Mesangial Cell-Specific Antibodies Are Central to the Pathogenesis of Lupus Nephritis. Journal of Immunology Research. 2011. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-994524
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994524