CD4 T-Cell-Independent Antibody Response Reduces Enterovirus 71 Lethality in Mice by Decreasing Tissue Viral Loads
Joint Authors
Kao, Chia-Min
Chang, Tung-Miao
Wang, Li-Chiu
Su, Ih-Jen
Chen, Shun-Hua
Ling, Pin
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Enterovirus 71 (EV71) has induced fatal encephalitis in hundreds of thousands of infants and young children in the Asia-Pacific region since the past decade.
Lymphocyte and antibody responses have been suspected to aggravate EV71-induced neurological symptoms, so anti-inflammatory agents have been used to treat patients with neurological symptoms.
In the present study, we found that mice deficient in CD4+ T cells were resistant to EV71 infection as wild-type mice, whereas mice deficient in B cells were highly susceptible to viral infection.
Compensation of CD4 T-cell function by other immune cells was not likely, because wild-type mice depleted of CD4+ T cells were also resistant to viral infection.
Infected CD4 T-cell-deficient mice produced virus-specific neutralizing antibodies, IgM and IgG.
Moreover, adoptive transfer of the virus-specific antibody produced by infected CD4 T-cell-deficient mice protected B-cell-deficient mice from infection by reducing tissue viral loads.
Collectively, our results show that the CD4 T-cell-independent antibody response promotes the survival of EV71-infected mice and suggest great potential for the use of vaccines and neutralizing antibodies to reduce fatal symptoms in patients.
American Psychological Association (APA)
Wang, Li-Chiu& Kao, Chia-Min& Ling, Pin& Su, Ih-Jen& Chang, Tung-Miao& Chen, Shun-Hua. 2012. CD4 T-Cell-Independent Antibody Response Reduces Enterovirus 71 Lethality in Mice by Decreasing Tissue Viral Loads. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-994525
Modern Language Association (MLA)
Wang, Li-Chiu…[et al.]. CD4 T-Cell-Independent Antibody Response Reduces Enterovirus 71 Lethality in Mice by Decreasing Tissue Viral Loads. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-994525
American Medical Association (AMA)
Wang, Li-Chiu& Kao, Chia-Min& Ling, Pin& Su, Ih-Jen& Chang, Tung-Miao& Chen, Shun-Hua. CD4 T-Cell-Independent Antibody Response Reduces Enterovirus 71 Lethality in Mice by Decreasing Tissue Viral Loads. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-994525
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994525