Genetics of SLE: Functional Relevance for MonocytesMacrophages in Disease
Joint Authors
Byrne, Jennifer C.
Ní Gabhann, Joan
Lazzari, Elisa
Jefferies, Caroline A.
Smith, Siobhán
Wynne, Claire
Mahony, Rebecca
Stacey, Kevin
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-19
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Genetic studies in the last 5 years have greatly facilitated our understanding of how the dysregulation of diverse components of the innate immune system contributes to pathophysiology of SLE.
A role for macrophages in the pathogenesis of SLE was first proposed as early as the 1980s following the discovery that SLE macrophages were defective in their ability to clear apoptotic cell debris, thus prolonging exposure of potential autoantigens to the adaptive immune response.
More recently, there is an emerging appreciation of the contribution both monocytes and macrophages play in orchestrating immune responses with perturbations in their activation or regulation leading to immune dysregulation.
This paper will focus on understanding the relevance of genes identified as being associated with innate immune function of monocytes and macrophages and development of SLE, particularly with respect to their role in (1) immune complex (IC) recognition and clearance, (2) nucleic acid recognition via toll-like receptors (TLRs) and downstream signalling, and (3) interferon signalling.
Particular attention will be paid to the functional consequences these genetic associations have for disease susceptibility or pathogenesis.
American Psychological Association (APA)
Byrne, Jennifer C.& Ní Gabhann, Joan& Lazzari, Elisa& Mahony, Rebecca& Smith, Siobhán& Stacey, Kevin…[et al.]. 2012. Genetics of SLE: Functional Relevance for MonocytesMacrophages in Disease. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-994526
Modern Language Association (MLA)
Byrne, Jennifer C.…[et al.]. Genetics of SLE: Functional Relevance for MonocytesMacrophages in Disease. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-15.
https://search.emarefa.net/detail/BIM-994526
American Medical Association (AMA)
Byrne, Jennifer C.& Ní Gabhann, Joan& Lazzari, Elisa& Mahony, Rebecca& Smith, Siobhán& Stacey, Kevin…[et al.]. Genetics of SLE: Functional Relevance for MonocytesMacrophages in Disease. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-994526
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994526