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Restoration of Innate and Adaptive Immune Responses by HCV Viral Inhibition with an Induction Approach Using Natural Interferon-Beta in Chronic Hepatitis C
Joint Authors
Imaizumi, N.
Haruna, Y.
Tanimura, H.
Kashiwamura, S.
Kashiwagi, T.
Kishida, Y.
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-27
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Chronic hepatitis C (CHC) is a serious medical problem necessitating more effective treatment.
This study investigated the hypothesis that an induction approach with nIFN-beta for 24 weeks followed by PEG-IFN-alpha+ribavirin (standard of care: SOC) for 48 weeks (novel combination treatment: NCT) would increase the initial virologic response rate and restore innate and adaptive immune responses in CHC.
Seven CHC patients with a high viral load and genotype 1b were treated with NCT.
Serum cytokine and chemokine levels were evaluated during NCT.
NCT prevented viral escape and breakthrough resulting in persistent viral clearance of HCVRNA.
IL-15 was increased at the end of induction therapy in both early virologic responders (EAVRs) and late virologic responders (LAVRs); CXCL-8, CXCL-10, and CCL-4 levels were significantly decreased (P<0.05) in EAVR but not in LAVR during NCT, and IL-12 increased significantly (P<0.05) and CXCL-8 decreased significantly (P<0.05) after the end of NCT in EAVR but not in LAVR.
NCT prevented viral breakthrough with viral clearance leading to improvement of innate and adaptive immunity resulting in a sustained virologic response (SVR).
NCT (n=8) achieved a higher SVR rate than SOC (n=8) in difficult-to-treat CHC patients with genotype 1 and high viral loads.
American Psychological Association (APA)
Kishida, Y.& Imaizumi, N.& Tanimura, H.& Haruna, Y.& Kashiwamura, S.& Kashiwagi, T.. 2012. Restoration of Innate and Adaptive Immune Responses by HCV Viral Inhibition with an Induction Approach Using Natural Interferon-Beta in Chronic Hepatitis C. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-994527
Modern Language Association (MLA)
Kishida, Y.…[et al.]. Restoration of Innate and Adaptive Immune Responses by HCV Viral Inhibition with an Induction Approach Using Natural Interferon-Beta in Chronic Hepatitis C. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-15.
https://search.emarefa.net/detail/BIM-994527
American Medical Association (AMA)
Kishida, Y.& Imaizumi, N.& Tanimura, H.& Haruna, Y.& Kashiwamura, S.& Kashiwagi, T.. Restoration of Innate and Adaptive Immune Responses by HCV Viral Inhibition with an Induction Approach Using Natural Interferon-Beta in Chronic Hepatitis C. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-994527
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994527