Host Susceptibility to Brucella abortus Infection Is More Pronounced in IFN-γ knockout than IL-12β2-Microglobulin Double-Deficient Mice
Joint Authors
Carvalho, Natalia B.
Macedo, Gilson Costa
Azevedo, Vasco
Vieira, Leda Quercia
Oliveira, Fernanda S.
Oliveira, Sérgio Costa
Brandão, Ana Paula M. S.
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Brucella abortus is a facultative intracellular bacterial pathogen that causes abortion in domestic animals and undulant fever in humans.
IFN-γ, IL-12, and CD8+ T lymphocytes are important components of host immune responses against B.
abortus.
Herein, IFN-γ and IL-12/β2-microglobulin (β2-m) knockout mice were used to determine whether CD8+ T cells and IL-12-dependent IFN-γ deficiency would be more critical to control B.
abortus infection compared to the lack of endogenous IFN-γ.
At 1 week after infection, IFN-γ KO and IL-12/β2-m KO mice showed increased numbers of bacterial load in spleens; however, at 3 weeks postinfection (p.i.), only IFN-γ KO succumbed to Brucella.
All IFN-γ KO had died at 16 days p.i.
whereas death within the IL-12/β2-m KO group was delayed and occurred at 32 days until 47 days postinfection.
Susceptibility of IL-12/β2-m KO animals to Brucella was associated to undetectable levels of IFN-γ in mouse splenocytes and inability of these cells to lyse Brucella-infected macrophages.
However, the lack of endogenous IFN-γ was found to be more important to control brucellosis than CD8+ T cells and IL-12-dependent IFN-γ deficiencies.
American Psychological Association (APA)
Brandão, Ana Paula M. S.& Oliveira, Fernanda S.& Carvalho, Natalia B.& Vieira, Leda Quercia& Azevedo, Vasco& Macedo, Gilson Costa…[et al.]. 2011. Host Susceptibility to Brucella abortus Infection Is More Pronounced in IFN-γ knockout than IL-12β2-Microglobulin Double-Deficient Mice. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-994530
Modern Language Association (MLA)
Brandão, Ana Paula M. S.…[et al.]. Host Susceptibility to Brucella abortus Infection Is More Pronounced in IFN-γ knockout than IL-12β2-Microglobulin Double-Deficient Mice. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-994530
American Medical Association (AMA)
Brandão, Ana Paula M. S.& Oliveira, Fernanda S.& Carvalho, Natalia B.& Vieira, Leda Quercia& Azevedo, Vasco& Macedo, Gilson Costa…[et al.]. Host Susceptibility to Brucella abortus Infection Is More Pronounced in IFN-γ knockout than IL-12β2-Microglobulin Double-Deficient Mice. Journal of Immunology Research. 2011. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-994530
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994530