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Influence of Dendritic Cells on B-Cell Responses during HIV Infection
Joint Authors
Poudrier, Johanne
Roger, Michel
Chagnon-Choquet, Josiane
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-10
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Dendritic cells (DCs) modulate B-cell differentiation, activation, and survival mainly through production of growth factors such as B lymphocyte stimulator (BLyS/BAFF).
DC populations have been reported to be affected in number, phenotype and function during HIV infection and such alterations may contribute to the dysregulation of the B-cell compartment.
Herein, we reflect on the potential impact of DC on the pathogenesis of HIV-related B cell disorders, and how DC status may modulate the outcome of mucosal B cell responses against HIV, which are pivotal to the control of disease.
A concept that could be extrapolated to the overall outcome of HIV disease, whereby control versus progression may reside in the host’s capacity to maintain DC homeostasis at mucosal sites, where DC populations present an inherent capacity of modulating the balance between tolerance and protection, and are amongst the earliest cell types to be exposed to the virus.
American Psychological Association (APA)
Poudrier, Johanne& Chagnon-Choquet, Josiane& Roger, Michel. 2012. Influence of Dendritic Cells on B-Cell Responses during HIV Infection. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-994531
Modern Language Association (MLA)
Poudrier, Johanne…[et al.]. Influence of Dendritic Cells on B-Cell Responses during HIV Infection. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-994531
American Medical Association (AMA)
Poudrier, Johanne& Chagnon-Choquet, Josiane& Roger, Michel. Influence of Dendritic Cells on B-Cell Responses during HIV Infection. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-994531
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994531