Frequent Detection of Anti-Tubercular-Glycolipid-IgG and -IgA Antibodies in Healthcare Workers with Latent Tuberculosis Infection in the Philippines
Joint Authors
Suzuki, Yasuhiko
Hattori, Toshio
Telan, Elizabeth Freda O.
Shiratori, Beata
Leano, Prisca Susan A.
Siddiqi, Umme Ruman
Ashino, Yugo
Chagan-Yasutan, Haorile
Saitoh, Hiroki
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-05
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Anti-tubercular-glycolipid-IgG (TBGL-IgG) and -IgA (TBGL-IgA) antibodies, and the QuantiFERON-TB Gold test (QFT) were compared in healthcare workers (HCWs, n=31) and asymptomatic human immunodeficiency virus-carriers (HIV-AC, n=56) in Manila.
In HCWs, 48%, 51%, and 19% were positive in QFT, TBGL-IgG, and -IgA, respectively.
The TBGL-IgG positivity was significantly higher (P=0.02) in QFT-positive than QFT-negative HCWs.
Both TBGL-IgG- and -IgA-positive cases were only found in QFT-positive HCWs (27%).
The plasma IFN-γ levels positively correlated with TBGL-IgA titers (r=0.74, P=0.005), but not TBGL-IgG titers in this group, indicating that mucosal immunity is involved in LTBI in immunocompetent individuals.
The QFT positivity in HIV-AC was 31% in those with CD4+ cell counts >350/μL and 12.5% in low CD4 group (<350/μL).
59 % and 29% were positive for TBGL-IgG and -IgA, respectively, in HIV-AC, but no association was found between QFT and TBGL assays.
TBGL-IgG-positive rates in QFT-positive and QFT-negative HIV-AC were 61% and 58%, and those of TBGL-IgA were 23% and 30%, respectively.
The titers of TBGL-IgA were associated with serum IgA (P=0.02) in HIV-AC.
Elevations of TBGL-IgG and -IgA were related to latent tuberculosis infection in HCWs, but careful interpretation is necessary in HIV-AC.
American Psychological Association (APA)
Siddiqi, Umme Ruman& Leano, Prisca Susan A.& Chagan-Yasutan, Haorile& Shiratori, Beata& Saitoh, Hiroki& Ashino, Yugo…[et al.]. 2012. Frequent Detection of Anti-Tubercular-Glycolipid-IgG and -IgA Antibodies in Healthcare Workers with Latent Tuberculosis Infection in the Philippines. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-994538
Modern Language Association (MLA)
Siddiqi, Umme Ruman…[et al.]. Frequent Detection of Anti-Tubercular-Glycolipid-IgG and -IgA Antibodies in Healthcare Workers with Latent Tuberculosis Infection in the Philippines. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-994538
American Medical Association (AMA)
Siddiqi, Umme Ruman& Leano, Prisca Susan A.& Chagan-Yasutan, Haorile& Shiratori, Beata& Saitoh, Hiroki& Ashino, Yugo…[et al.]. Frequent Detection of Anti-Tubercular-Glycolipid-IgG and -IgA Antibodies in Healthcare Workers with Latent Tuberculosis Infection in the Philippines. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-994538
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994538