Induction of Tolerance via the Sublingual Route: Mechanisms and Applications
Joint Authors
Moingeon, Philippe
Mascarell, Laurent
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The clinical efficacy of sublingual immunotherapy (SLIT) with natural allergen extracts has been established in IgE-dependent respiratory allergies to grass or tree pollens, as well as house dust mites.
Sublingual vaccines have an excellent safety record, documented with approximately 2 billion doses administered, as of today, in humans.
The oral immune system comprises various antigen-presenting cells, including Langerhans cells, as well as myeloid and plasmacytoid dendritic cells (DCs) with a distinct localisation in the mucosa, along the lamina propria and in subepithelial tissues, respectively.
In the absence of danger signals, all these DC subsets are tolerogenic in that they support the differentiation of Th1- and IL10-producing regulatory CD4+ T cells.
Oral tissues contain limited numbers of mast cells and eosinophils, mostly located in submucosal areas, thereby explaining the good safety profile of SLIT.
Resident oral Th1, Th2, and Th17 CD4+ T cells are located along the lamina propria, likely representing a defence mechanism against infectious pathogens.
Second-generation sublingual vaccines are being developed, based upon recombinant allergens expressed in a native conformation, possibly formulated with Th1/T reg adjuvants and/or mucoadhesive particulate vector systems specifically designed to target oral dendritic cells.
American Psychological Association (APA)
Moingeon, Philippe& Mascarell, Laurent. 2011. Induction of Tolerance via the Sublingual Route: Mechanisms and Applications. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-994543
Modern Language Association (MLA)
Moingeon, Philippe& Mascarell, Laurent. Induction of Tolerance via the Sublingual Route: Mechanisms and Applications. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-994543
American Medical Association (AMA)
Moingeon, Philippe& Mascarell, Laurent. Induction of Tolerance via the Sublingual Route: Mechanisms and Applications. Journal of Immunology Research. 2011. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-994543
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994543