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Cytotoxic Activity of Dendritic Cells as a Possible Mechanism of Negative Regulation of T Lymphocytes in Pulmonary Tuberculosis
Joint Authors
Sakhno, Ludmila V.
Chernykh, Elena R.
Tyrinova, Tamara V.
Nikonov, Sergey D.
Leplina, Olga Yu.
Shevela, Ekaterina Ya.
Zhdanov, Oleg A.
Ostanin, Alexander A.
Tikhonova, Marina A.
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The PD-1/B7-H1-mediated induction of T cell apoptosis/anergy as a possible mechanism of immune response failure was studied in 76 patients with pulmonary tuberculosis (TB) with normal and low-proliferative response to antigens of M.
tuberculosis (purified protein derivative (PPD)).
It was revealed that dendritic cells (DCs), generated in vitro from patient blood monocytes with GM-CSF + IFN-α, were characterized by increased B7-H1 expression, upproduction of IL-10, and reducing of allostimulatory activity in mixed lymphocyte culture (MLC).
Moreover, DCs of patients with TB were able to enhance T cell apoptosis and to block T-cell division in MLC.
It was shown that neutralizing anti-PD1 antibodies significantly decreased the proapoptogenic/tolerogenic effect of DCs.
Correlation analysis revealed a direct relationship between IL-10 production and level of B7-H1 expression in the general group of investigated patients.
It was demonstrated that generation of healthy donor DCs in the presence of IL-10 led to an increase in the number of DCs-expressed B7-H1 molecule, DC proapoptogenic activity, and a decrease in their allostimulatory activity.
Obviously, the revealed phenomenon of the PD-1/B7-H1-mediated pro-apoptogenic activity of DCs is clinically significant since the cytotoxic/tolerogenic potential of DCs is more pronounced in patients with PPD anergy.
American Psychological Association (APA)
Sakhno, Ludmila V.& Tikhonova, Marina A.& Tyrinova, Tamara V.& Leplina, Olga Yu.& Shevela, Ekaterina Ya.& Nikonov, Sergey D.…[et al.]. 2012. Cytotoxic Activity of Dendritic Cells as a Possible Mechanism of Negative Regulation of T Lymphocytes in Pulmonary Tuberculosis. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-994545
Modern Language Association (MLA)
Sakhno, Ludmila V.…[et al.]. Cytotoxic Activity of Dendritic Cells as a Possible Mechanism of Negative Regulation of T Lymphocytes in Pulmonary Tuberculosis. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-994545
American Medical Association (AMA)
Sakhno, Ludmila V.& Tikhonova, Marina A.& Tyrinova, Tamara V.& Leplina, Olga Yu.& Shevela, Ekaterina Ya.& Nikonov, Sergey D.…[et al.]. Cytotoxic Activity of Dendritic Cells as a Possible Mechanism of Negative Regulation of T Lymphocytes in Pulmonary Tuberculosis. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-994545
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994545