Macrophage Migration Inhibitory Factor in Fetoplacental Tissues from Preeclamptic Pregnancies with or without Fetal Growth Restriction
Joint Authors
Piccoli, Ettore
Romagnoli, Roberta
Marzioni, Daniela
Castellucci, Mario
Todros, Tullia
Cardaropoli, Simona
Paulesu, Luana
Rolfo, Alessandro
Vasario, Elena
Ietta, Francesca
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-04
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The proinflammatory cytokine MIF (macrophage migration inhibitory factor) is involved in physiological and pathological processes in pregnancy.
MIF maternal serum levels are increased in preeclampsia (PE).
We hypothesize that pregnancy tissues are the source of MIF overexpression in PE.
MIF protein was studied in maternal sera, placental tissues, fetal membranes, and umbilical cord of 8 control and 20 PE pregnancies: 10 with normal fetal growth (PE-AGA) and 10 with fetal growth restriction (PE-FGR).
MIF levels were significantly higher in PE-AGA membranes than in controls and PE-FGR.
In PE-FGR, MIF cord concentrations were higher than in PE-AGA while MIF placental levels were lower than in controls.
MIF maternal serum levels were higher in PE, compared to controls, and the difference was mainly due to PE-FGR samples.
These data support MIF involvement in PE pathogenesis and suggest that different pregnancy tissues contribute to MIF production in PE with and without fetoplacental compromise.
American Psychological Association (APA)
Cardaropoli, Simona& Paulesu, Luana& Romagnoli, Roberta& Ietta, Francesca& Marzioni, Daniela& Castellucci, Mario…[et al.]. 2011. Macrophage Migration Inhibitory Factor in Fetoplacental Tissues from Preeclamptic Pregnancies with or without Fetal Growth Restriction. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-994560
Modern Language Association (MLA)
Cardaropoli, Simona…[et al.]. Macrophage Migration Inhibitory Factor in Fetoplacental Tissues from Preeclamptic Pregnancies with or without Fetal Growth Restriction. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-994560
American Medical Association (AMA)
Cardaropoli, Simona& Paulesu, Luana& Romagnoli, Roberta& Ietta, Francesca& Marzioni, Daniela& Castellucci, Mario…[et al.]. Macrophage Migration Inhibitory Factor in Fetoplacental Tissues from Preeclamptic Pregnancies with or without Fetal Growth Restriction. Journal of Immunology Research. 2011. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-994560
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994560