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Ileal Inflammation May Trigger the Development of GP2-Specific Pancreatic Autoantibodies in Patients with Crohn’s Disease
Joint Authors
al-Sulttan, Faris
Forbes, Alastair
Bogdanos, Dimitrios P.
Liaskos, Christos
Romanidou, Ourania
Pavlidis, Polychronis
Mytilinaiou, Maria G.
Roggenbuck, Dirk
Conrad, Karsten
Smyk, Daniel S.
Koutsoumpas, Andreas L.
Rigopoulou, Eirini I.
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Why zymogen glycoprotein 2 (GP2), the Crohn’s disease (CD)-specific pancreatic autoantigen, is the major target of humoral autoimmunity in inflammatory bowel diseases (IBD) is uknown.
Recent evidence demonstrates that GP2 is also present on the apical surface of microfold (M) intestinal cells.
As the colon lacks GP2-rich M cells, we assumed that patients with colonic CD are seronegative for anti-GP2.
Anti-GP2 antibodies were tested in 225 CDs, including 45 patients with colonic location (L2), 45 with terminal ileum (L1) and 135 with ileocolonic involvement; 225 patients with ulcerative colitis (UC) were also tested.
Anti-GP2 reactivity was detected in 59 (26.2%) CDs and 15 (6.7%) UCs (P<0.001).
Only 5 CDs with L2 had anti-GP2 antibodies, compared to 54/180 (30.0%, P=0.0128) of the CDs with L1 and L3.
Anti-GP2 antibody positive CD patients had higher ASCA titres compared to seronegative cases.
Amongst the 128 CD patients with previous surgical intervention, 45 (35.0%) were anti-GP2 antibody positive compared to 14/97 (14.0%) without surgical (P<0.001).
Our data support the assumption that ileal inflammation is required for the development of anti-GP2 antibodies in CD, and suggest that the intestine rather than the pancreatic juice is the antigenic source required for the initiation of anti-GP2 antibodies.
American Psychological Association (APA)
Pavlidis, Polychronis& Romanidou, Ourania& Roggenbuck, Dirk& Mytilinaiou, Maria G.& al-Sulttan, Faris& Liaskos, Christos…[et al.]. 2012. Ileal Inflammation May Trigger the Development of GP2-Specific Pancreatic Autoantibodies in Patients with Crohn’s Disease. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-994563
Modern Language Association (MLA)
Pavlidis, Polychronis…[et al.]. Ileal Inflammation May Trigger the Development of GP2-Specific Pancreatic Autoantibodies in Patients with Crohn’s Disease. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-994563
American Medical Association (AMA)
Pavlidis, Polychronis& Romanidou, Ourania& Roggenbuck, Dirk& Mytilinaiou, Maria G.& al-Sulttan, Faris& Liaskos, Christos…[et al.]. Ileal Inflammation May Trigger the Development of GP2-Specific Pancreatic Autoantibodies in Patients with Crohn’s Disease. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-994563
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-994563