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Involvement of Stat1 in the Phagocytosis of M. avium
Joint Authors
Magnani, Mauro
Schiavano, Giuditta Fiorella
Buondelmonte, Costantina
Dominici, Sabrina
Celeste, Angela Gabriela
Brandi, Giorgio
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Mycobacterium avium is an intracellular pathogen preferentially infecting human macrophages where they activate the JAK/STAT1 pathway.
This activation enhances the survival of infected cells, but, at the same time, makes macrophages optimal targets for drugs development against p-tyr701stat1.
In this study, we demonstrate that the fast and transient activity of the JAK/STAT1 pathway occurs immediately after macrophages internalization of heat-killed M.
avium or inert particles.
Furthermore, we show that a persistent Stat1 pathway activation occurs only when an intracellular M.
avium infection is established in macrophages.
These results strongly indicate different mechanisms of p-tyr701Stat1 activation.
In particular, here we report findings aiming at explaining the short-time enhancement of p-tyr701Stat1 and shows its predominant relationship with FcγRs engagement during the internalization process.
Furthermore, we demonstrate that opsonized live M.
avium is phagocytosed by macrophages involving membrane receptors not related with JAK/STAT1 signalling pathway.
On the contrary, heat-inactivated bacilli or latex particles seem to be internalized only after involvement of FcγRs and subsequent Stat1 phosphorylation.
American Psychological Association (APA)
Dominici, Sabrina& Schiavano, Giuditta Fiorella& Magnani, Mauro& Buondelmonte, Costantina& Celeste, Angela Gabriela& Brandi, Giorgio. 2012. Involvement of Stat1 in the Phagocytosis of M. avium. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-996780
Modern Language Association (MLA)
Dominici, Sabrina…[et al.]. Involvement of Stat1 in the Phagocytosis of M. avium. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-996780
American Medical Association (AMA)
Dominici, Sabrina& Schiavano, Giuditta Fiorella& Magnani, Mauro& Buondelmonte, Costantina& Celeste, Angela Gabriela& Brandi, Giorgio. Involvement of Stat1 in the Phagocytosis of M. avium. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-996780
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-996780