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Immune Development and Intestinal Microbiota in Celiac Disease
Joint Authors
De Palma, Giada
Marcos, Ascensión
Olivares, Marta
Mujico, Jorge R.
Pozo-Rubio, Tamara
Nova, Esther
Sanz, Yolanda
Ferrer, Maria Desamparados
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-11
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Celiac disease (CD) is an immune-mediated enteropathy, triggered by dietary wheat gluten and similar proteins of barley and rye in genetically susceptible individuals.
The etiology of this disorder is complex, involving both environmental and genetic factors.
The major genetic risk factor for CD is represented by HLA-DQ genes, which account for approximately 40% of the genetic risk; however, only a small percentage of carriers develop the disease.
Gluten is the main environmental factor responsible for the signs and symptoms of the disease, but exposure to gluten does not fully explain the manifestation of CD.
Epidemiological and clinical data suggest that environmental factors other than gluten might play a role in disease development, including early feeding practices (e.g., breast milk versus formula and duration of breastfeeding), infections, and alterations in the intestinal microbiota composition.
Herein, we review what is known about the influence of dietary factors, exposure to infectious agents, and intestinal microbiota composition, particularly in early life, on the risk of developing CD, as well as the possible dietary strategies to induce or increase gluten tolerance.
American Psychological Association (APA)
Pozo-Rubio, Tamara& Olivares, Marta& Nova, Esther& De Palma, Giada& Mujico, Jorge R.& Ferrer, Maria Desamparados…[et al.]. 2012. Immune Development and Intestinal Microbiota in Celiac Disease. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-996781
Modern Language Association (MLA)
Pozo-Rubio, Tamara…[et al.]. Immune Development and Intestinal Microbiota in Celiac Disease. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-996781
American Medical Association (AMA)
Pozo-Rubio, Tamara& Olivares, Marta& Nova, Esther& De Palma, Giada& Mujico, Jorge R.& Ferrer, Maria Desamparados…[et al.]. Immune Development and Intestinal Microbiota in Celiac Disease. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-996781
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-996781