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Significance of CD44 and CD24 as Cancer Stem Cell Markers: An Enduring Ambiguity
Joint Authors
Elkord, Eyad
Jaggupilli, Appalaraju
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-30
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Cancer stem cell population is a subset of cells capable of dictating invasion, metastasis, heterogeneity, and therapeutic resistance in tumours.
Eradication of this rare population is a new insight in cancer treatment.
However, prospective identification, characterization, and isolation of these CSCs have been a major challenge.
Many studies were performed on surface markers for potential identification and isolation of CSCs.
Lack of universal expression of surface markers limits their usage and no best combination of markers has yet been confirmed to identify CSCs capable of initiating and metastasizing tumours.
CD44, a hyaluronic acid receptor, is one of the most commonly studied surface markers, which is expressed by almost every tumour cell.
CD24, a heat stable antigen, is another surface marker expressed in many tumour types.
However, their expression and prognostic value in isolating CSCs are still an enduring ambiguity.
In this critical review, we assess the role of CD44 and CD24 in tumour initiation, development, and metastasis.
We mainly focus on analysing the significance of CD44 and CD24 as CSC surface markers in combination or with other putative markers in different types of cancer.
American Psychological Association (APA)
Jaggupilli, Appalaraju& Elkord, Eyad. 2012. Significance of CD44 and CD24 as Cancer Stem Cell Markers: An Enduring Ambiguity. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-996795
Modern Language Association (MLA)
Jaggupilli, Appalaraju& Elkord, Eyad. Significance of CD44 and CD24 as Cancer Stem Cell Markers: An Enduring Ambiguity. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-996795
American Medical Association (AMA)
Jaggupilli, Appalaraju& Elkord, Eyad. Significance of CD44 and CD24 as Cancer Stem Cell Markers: An Enduring Ambiguity. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-996795
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-996795