Invariant NKT Cells as Novel Targets for Immunotherapy in Solid Tumors
Joint Authors
Demaria, Sandra
Pilones, Karsten A.
Aryankalayil, Joseph
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-17
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Natural killer T (NKT) cells are a small population of lymphocytes that possess characteristics of both innate and adaptive immune cells.
They are uniquely poised to respond rapidly to infection and inflammation and produce cytokines that critically shape the ensuing adaptive cellular response.
Therefore, they represent promising therapeutic targets.
In cancer, NKT cells are attributed a role in immunosurveillance.
NKT cells also act as potent activators of antitumor immunity when stimulated with a synthetic agonist in experimental models.
However, in some settings, NKT cells seem to act as suppressors and regulators of antitumor immunity.
Here we briefly review current data supporting these paradoxical roles of NKT cells and their regulation.
Increased understanding of the signals that determine the function of NKT cells in cancer will be essential to improve current strategies for NKT-cell-based immunotherapeutic approaches.
American Psychological Association (APA)
Pilones, Karsten A.& Aryankalayil, Joseph& Demaria, Sandra. 2012. Invariant NKT Cells as Novel Targets for Immunotherapy in Solid Tumors. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-996798
Modern Language Association (MLA)
Pilones, Karsten A.…[et al.]. Invariant NKT Cells as Novel Targets for Immunotherapy in Solid Tumors. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-996798
American Medical Association (AMA)
Pilones, Karsten A.& Aryankalayil, Joseph& Demaria, Sandra. Invariant NKT Cells as Novel Targets for Immunotherapy in Solid Tumors. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-996798
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-996798