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Regulatory T Cells Accumulate in the Lung Allergic Inflammation and Efficiently Suppress T-Cell Proliferation but Not Th2 Cytokine Production
Joint Authors
Russo, Momtchilo
Basso, Alexandre Salgado
Faustino, Lucas
Faria, Ana Maria Caetano
Keller, Alexandre Castro
Sardinha, Luiz Roberto
Mucida, Daniel
Carla Takenaka, Maisa
Bortoluci, Karina
Demengeot, Jocelyne
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-15
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Foxp3+CD25+CD4+ regulatory T cells are vital for peripheral tolerance and control of tissue inflammation.
In this study, we characterized the phenotype and monitored the migration and activity of regulatory T cells present in the airways of allergic or tolerant mice after allergen challenge.
To induce lung allergic inflammation, mice were sensitized twice with ovalbumin/aluminum hydroxide gel and challenged twice with intranasal ovalbumin.
Tolerance was induced by oral administration of ovalbumin for 5 consecutive days prior to OVA sensitization and challenge.
We detected regulatory T cells (Foxp3+CD25+CD4+ T cells) in the airways of allergic and tolerant mice; however, the number of regulatory T cells was more than 40-fold higher in allergic mice than in tolerant mice.
Lung regulatory T cells expressed an effector/memory phenotype (CCR4highCD62LlowCD44highCD54highCD69+) that distinguished them from naive regulatory T cells (CCR4intCD62LhighCD44intCD54intCD69−).
These regulatory T cells efficiently suppressed pulmonary T-cell proliferation but not Th2 cytokine production.
American Psychological Association (APA)
Faustino, Lucas& Mucida, Daniel& Keller, Alexandre Castro& Demengeot, Jocelyne& Bortoluci, Karina& Sardinha, Luiz Roberto…[et al.]. 2011. Regulatory T Cells Accumulate in the Lung Allergic Inflammation and Efficiently Suppress T-Cell Proliferation but Not Th2 Cytokine Production. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-996800
Modern Language Association (MLA)
Faustino, Lucas…[et al.]. Regulatory T Cells Accumulate in the Lung Allergic Inflammation and Efficiently Suppress T-Cell Proliferation but Not Th2 Cytokine Production. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-996800
American Medical Association (AMA)
Faustino, Lucas& Mucida, Daniel& Keller, Alexandre Castro& Demengeot, Jocelyne& Bortoluci, Karina& Sardinha, Luiz Roberto…[et al.]. Regulatory T Cells Accumulate in the Lung Allergic Inflammation and Efficiently Suppress T-Cell Proliferation but Not Th2 Cytokine Production. Journal of Immunology Research. 2011. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-996800
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-996800