![](/images/graphics-bg.png)
Tumor-Induced CD8+ T-Cell Dysfunction in Lung Cancer Patients
Joint Authors
Romero-Garcia, Susana
Prado-Garcia, Heriberto
Aguilar-Cazares, Dolores
Lopez-Gonzalez, Jose Sullivan
Meneses-Flores, Manuel
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-17
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Lung cancer is the leading cause of cancer deaths worldwide and one of the most common types of cancers.
The limited success of chemotherapy and radiotherapy regimes have highlighted the need to develop new therapies like antitumor immunotherapy.
CD8+ T-cells represent a major arm of the cell-mediated anti-tumor response and a promising target for developing T-cell-based immunotherapies against lung cancer.
Lung tumors, however, have been considered to possess poor immunogenicity; even so, lung tumor-specific CD8+ T-cell clones can be established that possess cytotoxicity against autologous tumor cells.
This paper will focus on the alterations induced in CD8+ T-cells by lung cancer.
Although memory CD8+ T-cells infiltrate lung tumors, in both tumor-infiltrating lymphocytes (TILs) and malignant pleural effusions, these cells are dysfunctional and the effector subset is reduced.
We propose that chronic presence of lung tumors induces dysfunctions in CD8+ T-cells and sensitizes them to activation-induced cell death, which may be associated with the poor clinical responses observed in immunotherapeutic trials.
Getting a deeper knowledge of the evasion mechanisms lung cancer induce in CD8+ T-cells should lead to further understanding of lung cancer biology, overcome tumor evasion mechanisms, and design improved immunotherapeutic treatments for lung cancer.
American Psychological Association (APA)
Prado-Garcia, Heriberto& Romero-Garcia, Susana& Aguilar-Cazares, Dolores& Meneses-Flores, Manuel& Lopez-Gonzalez, Jose Sullivan. 2012. Tumor-Induced CD8+ T-Cell Dysfunction in Lung Cancer Patients. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-996810
Modern Language Association (MLA)
Prado-Garcia, Heriberto…[et al.]. Tumor-Induced CD8+ T-Cell Dysfunction in Lung Cancer Patients. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-996810
American Medical Association (AMA)
Prado-Garcia, Heriberto& Romero-Garcia, Susana& Aguilar-Cazares, Dolores& Meneses-Flores, Manuel& Lopez-Gonzalez, Jose Sullivan. Tumor-Induced CD8+ T-Cell Dysfunction in Lung Cancer Patients. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-996810
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-996810