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Novel Strategies for Immunotherapy in Multiple Myeloma: Previous Experience and Future Directions
Joint Authors
Shimoni, Avichai
Nagler, Arnon
Beider, Katia
Danylesko, Ivetta
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-28, 28 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-10
Country of Publication
Egypt
No. of Pages
28
Main Subjects
Abstract EN
Multiple myeloma (MM) is a life-threatening haematological malignancy for which standard therapy is inadequate.
Autologous stem cell transplantation is a relatively effective treatment, but residual malignant sites may cause relapse.
Allogeneic transplantation may result in durable responses due to antitumour immunity mediated by donor lymphocytes.
However, morbidity and mortality related to graft-versus-host disease remain a challenge.
Recent advances in understanding the interaction between the immune system of the patient and the malignant cells are influencing the design of clinically more efficient study protocols for MM.
Cellular immunotherapy using specific antigen-presenting cells (APCs), to overcome aspects of immune incompetence in MM patients, has received great attention, and numerous clinical trials have evaluated the potential for dendritic cell (DC) vaccines as a novel immunotherapeutic approach.
This paper will summarize the data investigating aspects of immunity concerning MM, immunotherapy for patients with MM, and strategies, on the way, to target the plasma cell more selectively.
We also include the MM antigens and their specific antibodies that are of potential use for MM humoral immunotherapy, because they have demonstrated the most promising preclinical results.
American Psychological Association (APA)
Danylesko, Ivetta& Beider, Katia& Shimoni, Avichai& Nagler, Arnon. 2012. Novel Strategies for Immunotherapy in Multiple Myeloma: Previous Experience and Future Directions. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-28.
https://search.emarefa.net/detail/BIM-996813
Modern Language Association (MLA)
Danylesko, Ivetta…[et al.]. Novel Strategies for Immunotherapy in Multiple Myeloma: Previous Experience and Future Directions. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-28.
https://search.emarefa.net/detail/BIM-996813
American Medical Association (AMA)
Danylesko, Ivetta& Beider, Katia& Shimoni, Avichai& Nagler, Arnon. Novel Strategies for Immunotherapy in Multiple Myeloma: Previous Experience and Future Directions. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-28.
https://search.emarefa.net/detail/BIM-996813
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-996813