Role of Immune Escape Mechanisms in Hodgkin's Lymphoma Development and Progression: A Whole New World with Therapeutic Implications
Joint Authors
de la Cruz-Merino, Luis
Nogales Fernández, Esteban
Illescas Vacas, Ana
Henao Carrasco, Fernando
Álvaro, Tomás
Lejeune, Marylène
Grueso López, Ana
Pulla, Mariano Provencio
Callau, Cristina
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-24, 24 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-15
Country of Publication
Egypt
No. of Pages
24
Main Subjects
Abstract EN
Hodgkin's lymphoma represents one of the most frequent lymphoproliferative syndromes, especially in young population.
Although HL is considered one of the most curable tumors, a sizeable fraction of patients recur after successful upfront treatment or, less commonly, are primarily resistant.
This work tries to summarize the data on clinical, histological, pathological, and biological factors in HL, with special emphasis on the improvement of prognosis and their impact on therapeutical strategies.
The recent advances in our understanding of HL biology and immunology show that infiltrated immune cells and cytokines in the tumoral microenvironment may play different functions that seem tightly related with clinical outcomes.
Strategies aimed at interfering with the crosstalk between tumoral Reed-Sternberg cells and their cellular partners have been taken into account in the development of new immunotherapies that target different cell components of HL microenvironment.
This new knowledge will probably translate into a change in the antineoplastic treatments in HL in the next future and hopefully will increase the curability rates of this disease.
American Psychological Association (APA)
de la Cruz-Merino, Luis& Lejeune, Marylène& Nogales Fernández, Esteban& Henao Carrasco, Fernando& Callau, Cristina& Álvaro, Tomás…[et al.]. 2012. Role of Immune Escape Mechanisms in Hodgkin's Lymphoma Development and Progression: A Whole New World with Therapeutic Implications. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-24.
https://search.emarefa.net/detail/BIM-996814
Modern Language Association (MLA)
Callau, Cristina…[et al.]. Role of Immune Escape Mechanisms in Hodgkin's Lymphoma Development and Progression: A Whole New World with Therapeutic Implications. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-24.
https://search.emarefa.net/detail/BIM-996814
American Medical Association (AMA)
de la Cruz-Merino, Luis& Lejeune, Marylène& Nogales Fernández, Esteban& Henao Carrasco, Fernando& Callau, Cristina& Álvaro, Tomás…[et al.]. Role of Immune Escape Mechanisms in Hodgkin's Lymphoma Development and Progression: A Whole New World with Therapeutic Implications. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-24.
https://search.emarefa.net/detail/BIM-996814
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-996814