The Role of Airway Epithelial Cells in Response to Mycobacteria Infection
Joint Authors
Wang, Yujiong
Li, Yong
Liu, Xiaoming
Source
Journal of Immunology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-18
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Airway epithelial cells (AECs) are part of the frontline defense against infection of pathogens by providing both a physical barrier and immunological function.
The role of AECs in the innate and adaptive immune responses, through the production of antimicrobial molecules and proinflammatory factors against a variety of pathogens, has been well established.
Tuberculosis (TB), a contagious disease primarily affecting the lungs, is caused by the infection of various strains of mycobacteria.
In response to mycobacteria infection, epithelial expression of Toll-like receptors and surfactant proteins plays the most prominent roles in the recognition and binding of the pathogen, as well as the initiation of the immune response.
Moreover, the antimicrobial substances, proinflammatory factors secreted by AECs, composed a major part of the innate immune response and mediation of adaptive immunity against the pathogen.
Thus, a better understanding of the role and mechanism of AECs in response to mycobacteria will provide insight into the relationship of epithelial cells and lung immunocytes against TB, which may facilitate our understanding of the pathogenesis and immunological mechanism of pulmonary tuberculosis disease.
American Psychological Association (APA)
Li, Yong& Wang, Yujiong& Liu, Xiaoming. 2012. The Role of Airway Epithelial Cells in Response to Mycobacteria Infection. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-996827
Modern Language Association (MLA)
Li, Yong…[et al.]. The Role of Airway Epithelial Cells in Response to Mycobacteria Infection. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-996827
American Medical Association (AMA)
Li, Yong& Wang, Yujiong& Liu, Xiaoming. The Role of Airway Epithelial Cells in Response to Mycobacteria Infection. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-996827
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-996827